Welcome to the UPF Digital Repository

Spatiotemporal transcriptomic divergence across human and macaque brain development

Show simple item record

dc.contributor.author Zhu, Ying
dc.contributor.author Sousa, André M. M.
dc.contributor.author Gao, Tianliuyun
dc.contributor.author Skarica, Mario
dc.contributor.author Li, Mingfeng
dc.contributor.author Santpere Baró, Gabriel, 1981-
dc.contributor.author Esteller Cucala, Paula
dc.contributor.author Juan, David
dc.contributor.author Ferrández Peral, Luis, 1991-
dc.contributor.author Gulden, Forrest O.
dc.contributor.author Yang, Mo
dc.contributor.author Miller, Daniel J.
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Kawasawa, Yuka Imamura
dc.contributor.author Zhao, Hongyu
dc.contributor.author Sestan, Nenad
dc.date.accessioned 2019-12-17T08:02:49Z
dc.date.available 2019-12-17T08:02:49Z
dc.date.issued 2018
dc.identifier.citation Zhu Y, Sousa AMM, Gao T, Skarica M, Li M, Santpere G et al. Spatiotemporal transcriptomic divergence across human and macaque brain development. Science. 2018;362(6420):eaat8077. DOI: 10.1126/science.aat8077
dc.identifier.issn 0036-8075
dc.identifier.uri http://hdl.handle.net/10230/43179
dc.description.abstract Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. Integrative analysis with complementary human data revealed that global intraspecies (ontogenetic) and interspecies (phylogenetic) regional transcriptomic differences exhibit concerted cup-shaped patterns, with a late fetal-to-infancy (perinatal) convergence. Prenatal neocortical transcriptomic patterns revealed transient topographic gradients, whereas postnatal patterns largely reflected functional hierarchy. Genes exhibiting heterotopic and heterochronic divergence included those transiently enriched in the prenatal prefrontal cortex or linked to autism spectrum disorder and schizophrenia. Our findings shed light on transcriptomic programs underlying the evolution of human brain development and the pathogenesis of neuropsychiatric disorders.
dc.description.sponsorship Also supported by BFU2017-86471-P (MINECO/FEDER, UE), U01 MH106874 grant, Howard Hughes International Early Career, 3P30AG021342-16S2 (H.Z.); Obra Social “La Caixa” and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880) (T.M.-B.); a Formació de Personal Investigador fellowship from Generalitat de Catalunya (FI_B00122) (P.E.-C.); La Caixa Foundation (L.F.-P.); a Juan de la Cierva fellowship (FJCI-2016-29558) from MICINN (D.J.); and NIH grants MH109904 and MH106874, the Kavli Foundation, and the James S. McDonnell Foundation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Association for the Advancement of Science (AAAS)
dc.relation.ispartof Science. 2018;362(6420):eaat8077
dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science. 2018; 362(6420). pii: eaat8077. DOI 10.1126/science.aat8077.
dc.title Spatiotemporal transcriptomic divergence across human and macaque brain development
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1126/science.aat8077
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


Compliant to Partaking