Spatiotemporal transcriptomic divergence across human and macaque brain development
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- dc.contributor.author Zhu, Ying
- dc.contributor.author Sousa, André M. M.
- dc.contributor.author Gao, Tianliuyun
- dc.contributor.author Skarica, Mario
- dc.contributor.author Li, Mingfeng
- dc.contributor.author Santpere Baró, Gabriel, 1981-
- dc.contributor.author Esteller Cucala, Paula
- dc.contributor.author Juan, David
- dc.contributor.author Ferrández Peral, Luis, 1991-
- dc.contributor.author Gulden, Forrest O.
- dc.contributor.author Yang, Mo
- dc.contributor.author Miller, Daniel J.
- dc.contributor.author Marquès i Bonet, Tomàs, 1975-
- dc.contributor.author Kawasawa, Yuka Imamura
- dc.contributor.author Zhao, Hongyu
- dc.contributor.author Sestan, Nenad
- dc.date.accessioned 2019-12-17T08:02:49Z
- dc.date.available 2019-12-17T08:02:49Z
- dc.date.issued 2018
- dc.description.abstract Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. Integrative analysis with complementary human data revealed that global intraspecies (ontogenetic) and interspecies (phylogenetic) regional transcriptomic differences exhibit concerted cup-shaped patterns, with a late fetal-to-infancy (perinatal) convergence. Prenatal neocortical transcriptomic patterns revealed transient topographic gradients, whereas postnatal patterns largely reflected functional hierarchy. Genes exhibiting heterotopic and heterochronic divergence included those transiently enriched in the prenatal prefrontal cortex or linked to autism spectrum disorder and schizophrenia. Our findings shed light on transcriptomic programs underlying the evolution of human brain development and the pathogenesis of neuropsychiatric disorders.
- dc.description.sponsorship Also supported by BFU2017-86471-P (MINECO/FEDER, UE), U01 MH106874 grant, Howard Hughes International Early Career, 3P30AG021342-16S2 (H.Z.); Obra Social “La Caixa” and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880) (T.M.-B.); a Formació de Personal Investigador fellowship from Generalitat de Catalunya (FI_B00122) (P.E.-C.); La Caixa Foundation (L.F.-P.); a Juan de la Cierva fellowship (FJCI-2016-29558) from MICINN (D.J.); and NIH grants MH109904 and MH106874, the Kavli Foundation, and the James S. McDonnell Foundation.
- dc.format.mimetype application/pdf
- dc.identifier.citation Zhu Y, Sousa AMM, Gao T, Skarica M, Li M, Santpere G et al. Spatiotemporal transcriptomic divergence across human and macaque brain development. Science. 2018;362(6420):eaat8077. DOI: 10.1126/science.aat8077
- dc.identifier.doi http://dx.doi.org/10.1126/science.aat8077
- dc.identifier.issn 0036-8075
- dc.identifier.uri http://hdl.handle.net/10230/43179
- dc.language.iso eng
- dc.publisher American Association for the Advancement of Science (AAAS)
- dc.relation.ispartof Science. 2018;362(6420):eaat8077
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P
- dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science. 2018; 362(6420). pii: eaat8077. DOI 10.1126/science.aat8077.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.title Spatiotemporal transcriptomic divergence across human and macaque brain development
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion