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Changes in mammographic density over time and the risk of breast cancer: An observational cohort study

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dc.contributor.author Román, Marta
dc.contributor.author Sala, Maria
dc.contributor.author Baré, Marisa
dc.contributor.author Posso, Margarita
dc.contributor.author Vidal, Carmen
dc.contributor.author Louro, Javier
dc.contributor.author Sánchez, Mar
dc.contributor.author Peñalva, Lupe
dc.contributor.author Castells, Xavier
dc.contributor.author BELE Study Group
dc.date.accessioned 2019-11-20T08:45:07Z
dc.date.issued 2019
dc.identifier.citation Román M, Sala M, Baré M, Posso M, Vidal C, Louro J. et al. Changes in mammographic density over time and the risk of breast cancer: An observational cohort study. Breast. 2019 Aug;46:108-115. DOI 10.1016/j.breast.2019.04.007
dc.identifier.issn 0960-9776
dc.identifier.uri http://hdl.handle.net/10230/42899
dc.description.abstract BACKGROUND: The effect of changes in mammographic density over time on the risk of breast cancer remains inconclusive. METHODS: We used information from four centres of the Breast Cancer Screening Program in Spain in the period 1996-2015. We analysed individual level data from 117,388 women first screened age 50-54, with at least two screening examinations. Breast density was determined using the BI-RADS classification (A to D in increasing order) at earliest and latest screening examination. Adjusted Poisson regression models were used to estimate the relative risk (RR) and 95% confidence intervals (95%CI) of the association between changes in mammographic density and breast cancer risk over time. RESULTS: During an average 5.8 years of follow-up, 1592 (1.36%) women had a breast cancer diagnosis. An increase in density category increased breast cancer risk, and a decrease in density decreased the risk, compared with women who remained in the same BI-RADS category. Women whose density category increased from B to C or B to D had a RR of 1.55 (95%CI = 1.24-1.94) and 2.32 (95%CI = 1.48-3.63), respectively. The RR for women whose density increased from C to D was 1.51 (95%CI = 1.03-2.22). Changes in BI-RADS density were similarly associated with the risk for invasive cancer than for ductal carcinoma in situ. CONCLUSIONS: Although a modest proportion of women changed BI-RADS density category, mammographic density changes modulated the risk of breast cancer and identified women at a differential risk. Using two longitudinal measures of BI-RADS density could help target women for risk-based screening strategies.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.breast.2019.04.007
dc.title Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.breast.2019.04.007
dc.subject.keyword Breast neoplasms
dc.subject.keyword Longitudinal studies
dc.subject.keyword Mammographic density
dc.subject.keyword Mass screening
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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