Changes in mammographic density over time and the risk of breast cancer: An observational cohort study

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• dc.contributor.author Román, Marta
• dc.contributor.author Sala, Maria
• dc.contributor.author Baré, Marisa
• dc.contributor.author Posso, Margarita
• dc.contributor.author Vidal, Carmen
• dc.contributor.author Louro, Javier
• dc.contributor.author Sánchez, Mar
• dc.contributor.author Peñalva, Lupe
• dc.contributor.author Castells, Xavier
• dc.contributor.author BELE Study Group
• dc.date.accessioned 2019-11-20T08:45:07Z
• dc.date.issued 2019
• dc.description.abstract BACKGROUND: The effect of changes in mammographic density over time on the risk of breast cancer remains inconclusive. METHODS: We used information from four centres of the Breast Cancer Screening Program in Spain in the period 1996-2015. We analysed individual level data from 117,388 women first screened age 50-54, with at least two screening examinations. Breast density was determined using the BI-RADS classification (A to D in increasing order) at earliest and latest screening examination. Adjusted Poisson regression models were used to estimate the relative risk (RR) and 95% confidence intervals (95%CI) of the association between changes in mammographic density and breast cancer risk over time. RESULTS: During an average 5.8 years of follow-up, 1592 (1.36%) women had a breast cancer diagnosis. An increase in density category increased breast cancer risk, and a decrease in density decreased the risk, compared with women who remained in the same BI-RADS category. Women whose density category increased from B to C or B to D had a RR of 1.55 (95%CI = 1.24-1.94) and 2.32 (95%CI = 1.48-3.63), respectively. The RR for women whose density increased from C to D was 1.51 (95%CI = 1.03-2.22). Changes in BI-RADS density were similarly associated with the risk for invasive cancer than for ductal carcinoma in situ. CONCLUSIONS: Although a modest proportion of women changed BI-RADS density category, mammographic density changes modulated the risk of breast cancer and identified women at a differential risk. Using two longitudinal measures of BI-RADS density could help target women for risk-based screening strategies.
• dc.format.mimetype application/pdf
• dc.identifier.citation Román M, Sala M, Baré M, Posso M, Vidal C, Louro J. et al. Changes in mammographic density over time and the risk of breast cancer: An observational cohort study. Breast. 2019 Aug;46:108-115. DOI 10.1016/j.breast.2019.04.007
• dc.identifier.doi http://dx.doi.org/10.1016/j.breast.2019.04.007
• dc.identifier.issn 0960-9776
• dc.identifier.uri http://hdl.handle.net/10230/42899
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.breast.2019.04.007
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Breast neoplasms
• dc.subject.keyword Longitudinal studies
• dc.subject.keyword Mammographic density
• dc.subject.keyword Mass screening
• dc.title Changes in mammographic density over time and the risk of breast cancer: An observational cohort study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion