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Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial

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dc.contributor.author Boronat Rigol, Anna, 1990-
dc.contributor.author Mateus Rodriguez, Julian Andrés
dc.contributor.author Soldevila-Domenech, Natalia
dc.contributor.author Guerra, Mercè
dc.contributor.author Rodríguez-Morató, Jose, 1987-
dc.contributor.author Varon, Carlota
dc.contributor.author Muñoz Aguayo, Daniel
dc.contributor.author Barbosa, Francina
dc.contributor.author Morales, Juan Carlos
dc.contributor.author Gaedigk, Andreas
dc.contributor.author Langohr, Klaus
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Pérez Mañá, Clara
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Tyndale, Rachel F.
dc.contributor.author Torre Fornell, Rafael de la
dc.date.accessioned 2019-10-22T11:31:08Z
dc.date.issued 2019
dc.identifier.citation Boronat A, Mateus J, Soldevila-Domenech N, Guerra M, Rodríguez-Morató J, Varon C et al. Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial. Free Radic Biol Med. 2019;143:471-81. DOI: 10.1016/j.freeradbiomed.2019.08.032
dc.identifier.issn 0891-5849
dc.identifier.uri http://hdl.handle.net/10230/42480
dc.description.abstract Introduction: The simple phenol hydroxytyrosol (OHTyr) has been associated with the beneficial health effects of extra virgin olive oil. Pre-clinical studies have identified Tyr hydroxylation, mediated by cytochrome P450 isoforms CYP2A6 and CYP2D6, as an additional source of OHTyr. Aim: We aimed to (i) confirm Tyr to OHTyr bioconversion in vivo in humans, (ii) assess the cardiovascular benefits of this bioconversion, and (iii) determine their interaction with a polygenic activity score (PAS) from CYP2A6 and CYP2D6 genotypes. Methods: Randomized, crossover, controlled study. Individuals at cardiovascular risk (n = 33) received: white wine (WW) (females 1, males 2 standard drinks/day), WW plus Tyr capsules (WW + Tyr) (25 mg Tyr capsule, one per WW drink), and water (control) ad libitum. Participants were classified by a PAS as low versus normal activity metabolizers. Results: OHTyr recovery following WW + Tyr was higher than after other interventions (P < 0.05). Low PAS individuals had lower OHTyr/Tyr ratios compared to individuals with normal PAS. WW + Tyr improved endothelial function, increased plasma HDL-cholesterol and antithrombin IIII, and decreased plasma homocysteine, endothelin 1, and CD40L, P65/RELA, and CFH gene expression in peripheral blood mononuclear cells (p < 0.05). Combining Tyr capsule(s) with WW abolished the increase in iNOS, eNOS, VEGFA, and CHF expressions promoted by WW (p < 0.05). Conclusions: Tyr, and its partial biotransformation into OHTyr, promoted cardiovascular health-related benefits in humans after dietary doses of Tyr. The study design allowed the health effects of individual phenols to be singled out from the dietary matrix in which they are naturally found.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Free Radical Biology and Medicine. 2019;143:471-81
dc.rights © Elsevier http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.032
dc.title Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.032
dc.subject.keyword CYP2A6
dc.subject.keyword CYP2D6
dc.subject.keyword Endothelial function
dc.subject.keyword Hydroxytyrosol
dc.subject.keyword Tyrosol
dc.subject.keyword Wine
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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