Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial

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• dc.contributor.author Boronat Rigol, Anna, 1990-
• dc.contributor.author Mateus Rodriguez, Julian Andrés
• dc.contributor.author Soldevila-Domenech, Natalia
• dc.contributor.author Guerra, Mercè
• dc.contributor.author Rodríguez-Morató, Jose, 1987-
• dc.contributor.author Varon, Carlota
• dc.contributor.author Muñoz Aguayo, Daniel
• dc.contributor.author Barbosa, Francina
• dc.contributor.author Morales, Juan Carlos
• dc.contributor.author Gaedigk, Andreas
• dc.contributor.author Langohr, Klaus
• dc.contributor.author Covas Planells, Maria Isabel
• dc.contributor.author Pérez Mañá, Clara
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Tyndale, Rachel F.
• dc.contributor.author Torre Fornell, Rafael de la
• dc.date.accessioned 2019-10-22T11:31:08Z
• dc.date.issued 2019
• dc.description.abstract Introduction: The simple phenol hydroxytyrosol (OHTyr) has been associated with the beneficial health effects of extra virgin olive oil. Pre-clinical studies have identified Tyr hydroxylation, mediated by cytochrome P450 isoforms CYP2A6 and CYP2D6, as an additional source of OHTyr. Aim: We aimed to (i) confirm Tyr to OHTyr bioconversion in vivo in humans, (ii) assess the cardiovascular benefits of this bioconversion, and (iii) determine their interaction with a polygenic activity score (PAS) from CYP2A6 and CYP2D6 genotypes. Methods: Randomized, crossover, controlled study. Individuals at cardiovascular risk (n = 33) received: white wine (WW) (females 1, males 2 standard drinks/day), WW plus Tyr capsules (WW + Tyr) (25 mg Tyr capsule, one per WW drink), and water (control) ad libitum. Participants were classified by a PAS as low versus normal activity metabolizers. Results: OHTyr recovery following WW + Tyr was higher than after other interventions (P < 0.05). Low PAS individuals had lower OHTyr/Tyr ratios compared to individuals with normal PAS. WW + Tyr improved endothelial function, increased plasma HDL-cholesterol and antithrombin IIII, and decreased plasma homocysteine, endothelin 1, and CD40L, P65/RELA, and CFH gene expression in peripheral blood mononuclear cells (p < 0.05). Combining Tyr capsule(s) with WW abolished the increase in iNOS, eNOS, VEGFA, and CHF expressions promoted by WW (p < 0.05). Conclusions: Tyr, and its partial biotransformation into OHTyr, promoted cardiovascular health-related benefits in humans after dietary doses of Tyr. The study design allowed the health effects of individual phenols to be singled out from the dietary matrix in which they are naturally found.
• dc.format.mimetype application/pdf
• dc.identifier.citation Boronat A, Mateus J, Soldevila-Domenech N, Guerra M, Rodríguez-Morató J, Varon C et al. Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial. Free Radic Biol Med. 2019;143:471-81. DOI: 10.1016/j.freeradbiomed.2019.08.032
• dc.identifier.doi http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.032
• dc.identifier.issn 0891-5849
• dc.identifier.uri http://hdl.handle.net/10230/42480
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Free Radical Biology and Medicine. 2019;143:471-81
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.032
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword CYP2A6
• dc.subject.keyword CYP2D6
• dc.subject.keyword Endothelial function
• dc.subject.keyword Hydroxytyrosol
• dc.subject.keyword Tyrosol
• dc.subject.keyword Wine
• dc.title Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion