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The role of C-reactive protein levels on the association of physical activity with lung function in adults

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dc.contributor.author Fuertes, Elaine
dc.contributor.author Carsin, Anne-Elie
dc.contributor.author Garcia-Larsen, Vanessa
dc.contributor.author Guerra, Stefano
dc.contributor.author Pin, Isabelle
dc.contributor.author Leynaert, Bénédicte
dc.contributor.author Accordini, Simone
dc.contributor.author Martínez-Moratalla, Jesús
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Urrutia, Isabel
dc.contributor.author Le Gouellec, Audrey
dc.contributor.author Heinrich, Joachim
dc.contributor.author Gislason, Thorarinn
dc.contributor.author Jõgi, Rain
dc.contributor.author Janson, Christer
dc.contributor.author Jarvis, Deborah
dc.contributor.author García Aymerich, Judith
dc.date.accessioned 2019-10-10T10:55:19Z
dc.date.available 2019-10-10T10:55:19Z
dc.date.issued 2019
dc.identifier.citation Fuertes E, Carsin AE, Garcia-Larsen V, Guerra S, Pin I, Leynaert B et al. The role of C-reactive protein levels on the association of physical activity with lung function in adults. PLoS One. 2019;14(9):e0222578. DOI: 10.1371/journal.pone.0222578
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/42423
dc.description.abstract Objective: Regular physical activity may be associated with improved lung function via reduced systemic inflammation, although studies exploring this mechanism are rare. We evaluated the role of C-reactive protein in blood, which is a common marker of systemic inflammation, on the association of physical activity with forced expiratory volume in one second and forced vital capacity. Methods: Cross-sectional data on spirometry, C-reactive protein levels and self-reported physical activity (yes/no; ≥2 times and ≥1hr per week of vigorous physical activity) were available in the European Community Respiratory Health Survey (N = 2347 adults, 49.3% male, 28–56 years-old). A subsample was also assessed 10 years later using the International Physical Activity Questionnaire, and tertiles of Metabolic Equivalent of Task—minutes per week spent in vigorous, moderate and walking activities were calculated (N = 671, 49.6% male, 40–67 years-old). Adjusted cross-sectional mixed linear regression models and the “mediate” package in “R” were used to assess the presence of mediation. Results: Despite positive significant associations between nearly all physical activity metrics with forced expiratory volume in one second and forced vital capacity, there was no evidence that C-reactive protein levels played a role. An influence of C-reactive protein levels was only apparent in the smaller subsample when comparing the medium to low tertiles of moderate activity (mean difference [95% CIs]: 21.1ml [5.2, 41.9] for forced expiratory volume in one second and 17.3ml [2.6, 38.0] for forced vital capacity). Conclusions: In a population of adults, we found no consistent evidence that the association of physical activity with forced expiratory volume in one second or forced vital capacity is influenced by the level of C-reactive protein in blood.
dc.description.sponsorship The results reported herein correspond to the specific aims of the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Individual Fellowship scheme (H2020-MSCA-IF-2015; proposal number 704268; https://ec.europa.eu/research/mariecurieactions/actions/individual-fellowships_en), awarded to the Principal Investigator EF. These results also correspond to the specific aims of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), awarded to the Principal Investigator DJ, which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 633212 (https://ec.europa.eu/programmes/horizon2020/). The local investigators and funding agencies for the participating European Community Respiratory Health Survey (ECRHS II and ECRHS III) centres are reported in the Supplementary File. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One. 2019;14(9):e0222578
dc.rights © 2019 Fuertes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title The role of C-reactive protein levels on the association of physical activity with lung function in adults
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0222578
dc.subject.keyword Physical activity
dc.subject.keyword Pulmonary function
dc.subject.keyword C-reactive proteins
dc.subject.keyword Inflammation
dc.subject.keyword Smoking habits
dc.subject.keyword Health surveys
dc.subject.keyword Professions
dc.subject.keyword Questionnaires
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/704268
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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