The role of C-reactive protein levels on the association of physical activity with lung function in adults

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• dc.contributor.author Fuertes, Elaine
• dc.contributor.author Carsin, Anne-Elie
• dc.contributor.author Garcia-Larsen, Vanessa
• dc.contributor.author Guerra, Stefano
• dc.contributor.author Pin, Isabelle
• dc.contributor.author Leynaert, Bénédicte
• dc.contributor.author Accordini, Simone
• dc.contributor.author Martínez-Moratalla, Jesús
• dc.contributor.author Antó i Boqué, Josep Maria
• dc.contributor.author Urrutia, Isabel
• dc.contributor.author Le Gouellec, Audrey
• dc.contributor.author Heinrich, Joachim
• dc.contributor.author Gislason, Thorarinn
• dc.contributor.author Jõgi, Rain
• dc.contributor.author Janson, Christer
• dc.contributor.author Jarvis, Deborah
• dc.contributor.author García Aymerich, Judith
• dc.date.accessioned 2019-10-10T10:55:19Z
• dc.date.available 2019-10-10T10:55:19Z
• dc.date.issued 2019
• dc.description.abstract Objective: Regular physical activity may be associated with improved lung function via reduced systemic inflammation, although studies exploring this mechanism are rare. We evaluated the role of C-reactive protein in blood, which is a common marker of systemic inflammation, on the association of physical activity with forced expiratory volume in one second and forced vital capacity. Methods: Cross-sectional data on spirometry, C-reactive protein levels and self-reported physical activity (yes/no; ≥2 times and ≥1hr per week of vigorous physical activity) were available in the European Community Respiratory Health Survey (N = 2347 adults, 49.3% male, 28–56 years-old). A subsample was also assessed 10 years later using the International Physical Activity Questionnaire, and tertiles of Metabolic Equivalent of Task—minutes per week spent in vigorous, moderate and walking activities were calculated (N = 671, 49.6% male, 40–67 years-old). Adjusted cross-sectional mixed linear regression models and the “mediate” package in “R” were used to assess the presence of mediation. Results: Despite positive significant associations between nearly all physical activity metrics with forced expiratory volume in one second and forced vital capacity, there was no evidence that C-reactive protein levels played a role. An influence of C-reactive protein levels was only apparent in the smaller subsample when comparing the medium to low tertiles of moderate activity (mean difference [95% CIs]: 21.1ml [5.2, 41.9] for forced expiratory volume in one second and 17.3ml [2.6, 38.0] for forced vital capacity). Conclusions: In a population of adults, we found no consistent evidence that the association of physical activity with forced expiratory volume in one second or forced vital capacity is influenced by the level of C-reactive protein in blood.
• dc.description.sponsorship The results reported herein correspond to the specific aims of the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Individual Fellowship scheme (H2020-MSCA-IF-2015; proposal number 704268; https://ec.europa.eu/research/mariecurieactions/actions/individual-fellowships_en), awarded to the Principal Investigator EF. These results also correspond to the specific aims of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), awarded to the Principal Investigator DJ, which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 633212 (https://ec.europa.eu/programmes/horizon2020/). The local investigators and funding agencies for the participating European Community Respiratory Health Survey (ECRHS II and ECRHS III) centres are reported in the Supplementary File. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fuertes E, Carsin AE, Garcia-Larsen V, Guerra S, Pin I, Leynaert B et al. The role of C-reactive protein levels on the association of physical activity with lung function in adults. PLoS One. 2019;14(9):e0222578. DOI: 10.1371/journal.pone.0222578
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0222578
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/42423
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS One. 2019;14(9):e0222578
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/704268
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
• dc.rights © 2019 Fuertes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Physical activity
• dc.subject.keyword Pulmonary function
• dc.subject.keyword C-reactive proteins
• dc.subject.keyword Inflammation
• dc.subject.keyword Smoking habits
• dc.subject.keyword Health surveys
• dc.subject.keyword Professions
• dc.subject.keyword Questionnaires
• dc.title The role of C-reactive protein levels on the association of physical activity with lung function in adults
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion