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ATP, Mg2+, nuclear phase separation, and genome accessibility

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dc.contributor.author Wright, Roni H.G.
dc.contributor.author Le Dily, François
dc.contributor.author Beato, Miguel
dc.date.accessioned 2019-10-02T10:02:08Z
dc.date.available 2019-10-02T10:02:08Z
dc.date.issued 2019
dc.identifier.citation Wright RHG, Le Dily F, Beato M. ATP, Mg2+, nuclear phase separation, and genome accessibility. Trends Biochem Sci. 2019;44(7):565-74. DOI: 10.1016/j.tibs.2019.03.001
dc.identifier.issn 0968-0004
dc.identifier.uri http://hdl.handle.net/10230/42371
dc.description.abstract Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital importance. Recently, understanding of chromatin hierarchical folding has increased together with the discovery of membrane-less organelles which are distinct, dynamic liquid droplets that merge and expand within the nucleus. These 'sieve'-like regions may compartmentalize and separate functionally distinct regions of chromatin. This article aims to discuss recent studies on nuclear phase within the context of poly(ADP-ribose), ATP, and Mg2+ levels, and we propose a combinatorial complex role for these molecules in phase separation and genome regulation. We also discuss the implications of this process for gene regulation and discuss possible strategies to test this.
dc.description.sponsorship The experimental work mentioned was supported by the European Research Council (Project 4D Genome 609989), the Ministerio de Economía y Competitividad (project G62426937), and the Generalitat de Catalunya (project Agència de Gestió d'Ajuts Universitaris i de Recerca SGR 575).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Trends in Biochemical Sciences. 2019;44(7):565-74
dc.rights © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title ATP, Mg2+, nuclear phase separation, and genome accessibility
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.tibs.2019.03.001
dc.subject.keyword Chromatin dynamics
dc.subject.keyword 3D genome topology
dc.subject.keyword Phase separation
dc.subject.keyword Membrane-less organelles
dc.subject.keyword Gene regulation
dc.subject.keyword Nuclear ATP
dc.subject.keyword PARylation
dc.subject.keyword Magnesium
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/609989
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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