ATP, Mg2+, nuclear phase separation, and genome accessibility
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- dc.contributor.author Wright, Roni H.G.
- dc.contributor.author Le Dily, François
- dc.contributor.author Beato, Miguel
- dc.date.accessioned 2019-10-02T10:02:08Z
- dc.date.available 2019-10-02T10:02:08Z
- dc.date.issued 2019
- dc.description.abstract Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital importance. Recently, understanding of chromatin hierarchical folding has increased together with the discovery of membrane-less organelles which are distinct, dynamic liquid droplets that merge and expand within the nucleus. These 'sieve'-like regions may compartmentalize and separate functionally distinct regions of chromatin. This article aims to discuss recent studies on nuclear phase within the context of poly(ADP-ribose), ATP, and Mg2+ levels, and we propose a combinatorial complex role for these molecules in phase separation and genome regulation. We also discuss the implications of this process for gene regulation and discuss possible strategies to test this.
- dc.description.sponsorship The experimental work mentioned was supported by the European Research Council (Project 4D Genome 609989), the Ministerio de Economía y Competitividad (project G62426937), and the Generalitat de Catalunya (project Agència de Gestió d'Ajuts Universitaris i de Recerca SGR 575).
- dc.format.mimetype application/pdf
- dc.identifier.citation Wright RHG, Le Dily F, Beato M. ATP, Mg2+, nuclear phase separation, and genome accessibility. Trends Biochem Sci. 2019;44(7):565-74. DOI: 10.1016/j.tibs.2019.03.001
- dc.identifier.doi http://dx.doi.org/10.1016/j.tibs.2019.03.001
- dc.identifier.issn 0968-0004
- dc.identifier.uri http://hdl.handle.net/10230/42371
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Trends in Biochemical Sciences. 2019;44(7):565-74
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/609989
- dc.rights © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Chromatin dynamics
- dc.subject.keyword 3D genome topology
- dc.subject.keyword Phase separation
- dc.subject.keyword Membrane-less organelles
- dc.subject.keyword Gene regulation
- dc.subject.keyword Nuclear ATP
- dc.subject.keyword PARylation
- dc.subject.keyword Magnesium
- dc.title ATP, Mg2+, nuclear phase separation, and genome accessibility
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion