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Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals

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dc.contributor.author Brugulat Serrat, Anna, 1986-
dc.contributor.author Salvadó, Gemma
dc.contributor.author Sudre, Carole H.
dc.contributor.author Grau-Rivera, Oriol
dc.contributor.author Suárez-Calvet, Marc
dc.contributor.author Falcón, Carles
dc.contributor.author Sánchez Benavides, Gonzalo
dc.contributor.author Gramunt Fombuena, Nina
dc.contributor.author Fauria, Karine
dc.contributor.author Cardoso, M. Jorge
dc.contributor.author Barkhof, Frederik
dc.contributor.author Molinuevo, José Luis
dc.contributor.author Gispert López, Juan Domingo
dc.contributor.author ALFA Study
dc.date.accessioned 2019-09-06T14:15:44Z
dc.date.available 2019-09-06T14:15:44Z
dc.date.issued 2019
dc.identifier.citation Brugulat-Serrat A, Salvadó G, Sudre CH, Grau-Rivera O, Suárez-Calvet M, Falcon C et al. Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals. Brain Imaging Behav. 2019 Jul 5 [Epub ahead of print]. DOI: 10.1007/s11682-019-00151-2
dc.identifier.issn 1931-7557
dc.identifier.uri http://hdl.handle.net/10230/42252
dc.description.abstract White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and regional distribution of WMH on episodic memory and executive function in middle-aged cognitively unimpaired participants [N = 561 (45-75 years)] enriched for Alzheimer's disease risk factors. WMH were automatically segmented from FLAIR, T1 and FSE MR images. WMH load was calculated both globally and regionally. At each cerebral lobe, regional WMH load was measured at four equidistant layers extending from the lateral ventricles to juxtacortical areas. Cognition was measured by The Memory Binding Test (MBT) and WAIS-IV subtests. Global composite z-scores were calculated for the two cognitive domains. Association between global and regional WMH measurements were sought against cognitive measures, both in global composite scores and in individual subtests. We adjusted cognition and WMH burden for the main sociodemographic (age, sex and education) and genetic factors (APOE-ε4). Memory and executive function were significantly associated with global WMH load. Regionally, lower executive performance was mainly associated with higher deep WMH load in frontal areas and, to a lower degree, in occipital, parietal and temporal regions. Lower episodic memory performance was correlated with higher WMH burden in deep frontal and occipital areas. Our novel methodological approach of regional analysis allowed us to reveal the association between cognition and WMH in strategic brain locations. Our results suggest that, even a small WMH load can impact cognition in cognitively unimpaired middle-aged subjects.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Brain Imaging Behav. 2019
dc.rights © 2019 Anna Brugulat-Serrat et al. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s11682-019-00151-2
dc.subject.keyword White matter lesions
dc.subject.keyword Magnetic resonance imaging
dc.subject.keyword Preclinical Alzheimer’s disease
dc.subject.keyword Cardiovascular risk
dc.subject.keyword Hypertension
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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