Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
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- dc.contributor.author Brugulat Serrat, Anna, 1986-
- dc.contributor.author Salvadó, Gemma
- dc.contributor.author Sudre, Carole H.
- dc.contributor.author Grau-Rivera, Oriol
- dc.contributor.author Suárez-Calvet, Marc
- dc.contributor.author Falcón, Carles
- dc.contributor.author Sánchez Benavides, Gonzalo
- dc.contributor.author Gramunt Fombuena, Nina
- dc.contributor.author Fauria, Karine
- dc.contributor.author Cardoso, M. Jorge
- dc.contributor.author Barkhof, Frederik
- dc.contributor.author Molinuevo, José Luis
- dc.contributor.author Gispert López, Juan Domingo
- dc.contributor.author ALFA Study
- dc.date.accessioned 2019-09-06T14:15:44Z
- dc.date.available 2019-09-06T14:15:44Z
- dc.date.issued 2019
- dc.description.abstract White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and regional distribution of WMH on episodic memory and executive function in middle-aged cognitively unimpaired participants [N = 561 (45-75 years)] enriched for Alzheimer's disease risk factors. WMH were automatically segmented from FLAIR, T1 and FSE MR images. WMH load was calculated both globally and regionally. At each cerebral lobe, regional WMH load was measured at four equidistant layers extending from the lateral ventricles to juxtacortical areas. Cognition was measured by The Memory Binding Test (MBT) and WAIS-IV subtests. Global composite z-scores were calculated for the two cognitive domains. Association between global and regional WMH measurements were sought against cognitive measures, both in global composite scores and in individual subtests. We adjusted cognition and WMH burden for the main sociodemographic (age, sex and education) and genetic factors (APOE-ε4). Memory and executive function were significantly associated with global WMH load. Regionally, lower executive performance was mainly associated with higher deep WMH load in frontal areas and, to a lower degree, in occipital, parietal and temporal regions. Lower episodic memory performance was correlated with higher WMH burden in deep frontal and occipital areas. Our novel methodological approach of regional analysis allowed us to reveal the association between cognition and WMH in strategic brain locations. Our results suggest that, even a small WMH load can impact cognition in cognitively unimpaired middle-aged subjects.
- dc.format.mimetype application/pdf
- dc.identifier.citation Brugulat-Serrat A, Salvadó G, Sudre CH, Grau-Rivera O, Suárez-Calvet M, Falcon C et al. Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals. Brain Imaging Behav. 2019 Jul 5 [Epub ahead of print]. DOI: 10.1007/s11682-019-00151-2
- dc.identifier.doi http://dx.doi.org/10.1007/s11682-019-00151-2
- dc.identifier.issn 1931-7557
- dc.identifier.uri http://hdl.handle.net/10230/42252
- dc.language.iso eng
- dc.publisher Springer
- dc.relation.ispartof Brain Imaging Behav. 2019
- dc.rights © 2019 Anna Brugulat-Serrat et al. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword White matter lesions
- dc.subject.keyword Magnetic resonance imaging
- dc.subject.keyword Preclinical Alzheimer’s disease
- dc.subject.keyword Cardiovascular risk
- dc.subject.keyword Hypertension
- dc.title Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion