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Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial

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dc.contributor.author Sánchez-Rodriguez, Estefanía
dc.contributor.author Biel-Glesson, Sara
dc.contributor.author Fernández-Navarro, Jose-Ramón
dc.contributor.author Calleja, Miguel Angel
dc.contributor.author Espejo-Calvo, Juan A.
dc.contributor.author Gil-Extremera, Blas
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Vilchez, Pedro
dc.contributor.author Alche, Juan de Dios
dc.contributor.author Martínez de Victoria, Emilio
dc.contributor.author Gil, Angel
dc.contributor.author Mesa, Maria-Dolores
dc.date.accessioned 2019-07-31T06:11:44Z
dc.date.available 2019-07-31T06:11:44Z
dc.date.issued 2019
dc.identifier.citation Sanchez-Rodriguez E, Biel-Glesson S, Fernandez-Navarro JR, Calleja MA, Espejo-Calvo JA, Gil-Extremera B, de la Torre R, Fito M, Covas MI, Vilchez P, Alche JD, Martinez de Victoria E, Gil A, Mesa MD. Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial. Nutrients. 2019; 11(3). pii: E561. DOI 10.3390/nu11030561
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/42209
dc.description.abstract A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of triterpenes), and a functional olive oil (FOO, 487 ppm of phenolic compounds and enriched with 389 ppm of triterpenes) supplementation (30 mL per day) during three weeks would provide additional health benefits to those produced by a standard VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes) on oxidative and inflammatory biomarkers. Fifty-one healthy adults participated in a randomized, crossover, and controlled study. Urinary 8-hidroxy-2'-deoxyguanosine, plasma interleukin-8 (IL-8), and tumor necrosis factor α (TNF- α) concentrations were lower after the intervention with the FOO than after the OVOO (p = 0.033, p = 0.011 and p = 0.020, respectively). In addition, IL-8 was lower after the intervention with FOO than after VOO intervention (p = 0.002). This study provides a first level of evidence on the in vivo health benefits of olive oil triterpenes (oleanolic and maslinic acids) in healthy humans, decreasing DNA oxidation and plasma inflammatory biomarkers. The trial was registered in ClinicalTrials.gov ID: NCT02520739.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Nutrients. 2019; 11(3). pii: E561
dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu11030561
dc.subject.keyword Olive oil
dc.subject.keyword Virgin olive oil
dc.subject.keyword Triterpenes
dc.subject.keyword Phenolic compounds
dc.subject.keyword Cardiovascular diseases
dc.subject.keyword Maslinic acid
dc.subject.keyword Oleanolic acid
dc.subject.keyword Oxidative stress
dc.subject.keyword 8-hidroxy-2′-deoxyguanosine
dc.subject.keyword TNF-alpha
dc.subject.keyword Interleukin-8
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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