Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial
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- dc.contributor.author Sánchez-Rodriguez, Estefanía
- dc.contributor.author Biel-Glesson, Sara
- dc.contributor.author Fernández-Navarro, Jose-Ramón
- dc.contributor.author Calleja, Miguel Angel
- dc.contributor.author Espejo-Calvo, Juan A.
- dc.contributor.author Gil-Extremera, Blas
- dc.contributor.author Torre Fornell, Rafael de la
- dc.contributor.author Fitó Colomer, Montserrat
- dc.contributor.author Covas Planells, Maria Isabel
- dc.contributor.author Vilchez, Pedro
- dc.contributor.author Alche, Juan de Dios
- dc.contributor.author Martínez de Victoria, Emilio
- dc.contributor.author Gil, Angel
- dc.contributor.author Mesa, Maria-Dolores
- dc.date.accessioned 2019-07-31T06:11:44Z
- dc.date.available 2019-07-31T06:11:44Z
- dc.date.issued 2019
- dc.description.abstract A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of triterpenes), and a functional olive oil (FOO, 487 ppm of phenolic compounds and enriched with 389 ppm of triterpenes) supplementation (30 mL per day) during three weeks would provide additional health benefits to those produced by a standard VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes) on oxidative and inflammatory biomarkers. Fifty-one healthy adults participated in a randomized, crossover, and controlled study. Urinary 8-hidroxy-2'-deoxyguanosine, plasma interleukin-8 (IL-8), and tumor necrosis factor α (TNF- α) concentrations were lower after the intervention with the FOO than after the OVOO (p = 0.033, p = 0.011 and p = 0.020, respectively). In addition, IL-8 was lower after the intervention with FOO than after VOO intervention (p = 0.002). This study provides a first level of evidence on the in vivo health benefits of olive oil triterpenes (oleanolic and maslinic acids) in healthy humans, decreasing DNA oxidation and plasma inflammatory biomarkers. The trial was registered in ClinicalTrials.gov ID: NCT02520739.
- dc.format.mimetype application/pdf
- dc.identifier.citation Sanchez-Rodriguez E, Biel-Glesson S, Fernandez-Navarro JR, Calleja MA, Espejo-Calvo JA, Gil-Extremera B et al. Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial. Nutrients. 2019;11(3):e561. DOI: 10.3390/nu11030561
- dc.identifier.doi http://dx.doi.org/10.3390/nu11030561
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/42209
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2019;11(3):e561
- dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Olive oil
- dc.subject.keyword Virgin olive oil
- dc.subject.keyword Triterpenes
- dc.subject.keyword Phenolic compounds
- dc.subject.keyword Cardiovascular diseases
- dc.subject.keyword Maslinic acid
- dc.subject.keyword Oleanolic acid
- dc.subject.keyword Oxidative stress
- dc.subject.keyword 8-hidroxy-2′-deoxyguanosine
- dc.subject.keyword TNF-alpha
- dc.subject.keyword Interleukin-8
- dc.title Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion