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Blood Development: Hematopoietic Stem Cell Dependence and Independence

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dc.contributor.author Dzierzak, Elaine
dc.contributor.author Bigas Salvans, Anna
dc.date.accessioned 2019-03-26T09:41:02Z
dc.date.issued 2018
dc.identifier.citation Dzierzak E, Bigas A. Blood Development: Hematopoietic Stem Cell Dependence and Independence. Cell Stem Cell. 2018 May 3;22(5):639-651. DOI: 10.1016/j.stem.2018.04.015
dc.identifier.issn 1875-9777
dc.identifier.uri http://hdl.handle.net/10230/36965
dc.description.abstract Evidence of the diversity and multi-layered organization of the hematopoietic system is leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all long-lived hematopoietic cells derive from hematopoietic stem cells (HSCs). Here we review the current knowledge on HSC-dependent cell lineages and HSC-independent tissue-resident hematopoietic cells and how they arise during embryonic development. Classical embryological and genetic experiments, cell fate tracing data, single-cell imaging, and transcriptomics studies provide information on the molecular/cell trajectories that form the complete hematopoietic system. We also discuss the current developmentally informed efforts toward generating engraftable and multilineage blood cells.
dc.description.sponsorship The authors thank Lluis Espinosa for critical reading of the review and lab members for helpful discussions. We acknowledge the support of the ERC Advanced Grant (341096 DENOVOHSC) to E.D. and SAF2016-75613-R from MINECO and PERIS- SLT002/16/00299 and 2017SGR135 from Generalitat de Catalunya to A.B.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.stem.2018.04.015
dc.subject.other Hematopoesi
dc.subject.other
dc.title Blood Development: Hematopoietic Stem Cell Dependence and Independence
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.stem.2018.04.015
dc.subject.keyword Embryonic hematopoiesis
dc.subject.keyword AGM
dc.subject.keyword EMP
dc.subject.keyword Hematopotoietic stem cell
dc.subject.keyword Hemogenic endothelium
dc.subject.keyword Primitive hematopoiesis
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016 -75613-R
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2019-05-31
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2019-05-31


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