Blood Development: Hematopoietic Stem Cell Dependence and Independence
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Dzierzak, Elaine
- dc.contributor.author Bigas Salvans, Anna
- dc.date.accessioned 2019-03-26T09:41:02Z
- dc.date.issued 2018
- dc.description.abstract Evidence of the diversity and multi-layered organization of the hematopoietic system is leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all long-lived hematopoietic cells derive from hematopoietic stem cells (HSCs). Here we review the current knowledge on HSC-dependent cell lineages and HSC-independent tissue-resident hematopoietic cells and how they arise during embryonic development. Classical embryological and genetic experiments, cell fate tracing data, single-cell imaging, and transcriptomics studies provide information on the molecular/cell trajectories that form the complete hematopoietic system. We also discuss the current developmentally informed efforts toward generating engraftable and multilineage blood cells.
- dc.description.sponsorship The authors thank Lluis Espinosa for critical reading of the review and lab members for helpful discussions. We acknowledge the support of the ERC Advanced Grant (341096 DENOVOHSC) to E.D. and SAF2016-75613-R from MINECO and PERIS- SLT002/16/00299 and 2017SGR135 from Generalitat de Catalunya to A.B.
- dc.format.mimetype application/pdf
- dc.identifier.citation Dzierzak E, Bigas A. Blood Development: Hematopoietic Stem Cell Dependence and Independence. Cell Stem Cell. 2018 May 3;22(5):639-651. DOI: 10.1016/j.stem.2018.04.015
- dc.identifier.doi http://dx.doi.org/10.1016/j.stem.2018.04.015
- dc.identifier.issn 1875-9777
- dc.identifier.uri http://hdl.handle.net/10230/36965
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Cell Stem Cell. 2018 May 3;22(5):639-51
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016 -75613-R
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.stem.2018.04.015
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Embryonic hematopoiesis
- dc.subject.keyword AGM
- dc.subject.keyword EMP
- dc.subject.keyword Hematopotoietic stem cell
- dc.subject.keyword Hemogenic endothelium
- dc.subject.keyword Primitive hematopoiesis
- dc.subject.other Hematopoesi
- dc.subject.other
- dc.title Blood Development: Hematopoietic Stem Cell Dependence and Independence
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion