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A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma

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dc.contributor.author Hernández-Ruiz, Eugenia
dc.contributor.author Hernández Muñoz, María Inmaculada
dc.contributor.author Masferrer, Emili
dc.contributor.author Ferrandiz-Pulido, Carla
dc.contributor.author Andrades, Evelyn
dc.contributor.author Gimeno Beltran, Javier
dc.contributor.author Duran Jordà, Xavier, 1974-
dc.contributor.author García-Patos, Vicenç
dc.contributor.author Pujol Vallverdú, Ramon Maria
dc.contributor.author Toll Abelló, Agustín
dc.date.accessioned 2019-02-14T08:08:46Z
dc.date.available 2019-02-14T08:08:46Z
dc.date.issued 2019
dc.identifier.citation Hernández-Ruiz E, Hernández-Muñoz I, Masferrer E, Ferrándiz-Pulido C, Andrades E, Gimeno J, et al. A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma. Acta Derm Venereol. 2019 Jan 1;99(1):89-94. DOI: 10.2340/00015555-3025
dc.identifier.issn 0001-5555
dc.identifier.uri http://hdl.handle.net/10230/36584
dc.description.abstract Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carcinomas). Clinical and histopathological data were registered. The fibrotic reaction pattern was classified as mature, intermediate or immature depending on the presence of keloid-like collagen and myxoid stroma. The immature pattern (areas characterized by myxoid changes with no inflammation) was observed in 18 samples and its presence was significantly associated with immunosuppression, budding, desmoplasia, perineural invasion, anatomic level, tumoural depth and metastatic risk in the multivariate analysis. Our findings suggest that the presence of an immature myxoid fibrotic pattern, which can be easily identified by routine hematoxylin-eosin staining, is strongly associated with metastatic risk.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Society for Publication of Acta Dermato-Venereologica
dc.relation.ispartof Acta Dermato-Venereologica. 2019 Jan 1;99(1):89-94
dc.rights Journal Compilation © 2019 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.other Dermatologia
dc.title A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.2340/00015555-3025
dc.subject.keyword Metastasis
dc.subject.keyword Fibrosis
dc.subject.keyword Cutaneous squamous cell carcinoma.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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