Welcome to the UPF Digital Repository

Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain

Show simple item record

dc.contributor.author Román, Marta
dc.contributor.author Caicoya, Martin
dc.contributor.author Espinàs, Josep Alfons
dc.contributor.author Sala Serra, Maria
dc.contributor.author Torá Rocamora, Isabel, 1979-
dc.contributor.author Quinta, Maria J.
dc.contributor.author Vernet-Tomás, Maria
dc.contributor.author Saladié, Francina
dc.contributor.author Romero, Anabel
dc.contributor.author Sánchez, Mar
dc.contributor.author Baré, Marisa
dc.contributor.author Vidal, Carmen
dc.contributor.author Servitja Tormo, Sonia
dc.contributor.author Natal, Carmen
dc.contributor.author Corominas Torres, Josep Maria
dc.contributor.author Ferrer, Joana
dc.contributor.author Rodríguez Arana, Ana Maria
dc.contributor.author Castells, Xavier
dc.contributor.author BELE Study Group
dc.date.accessioned 2019-02-05T08:34:39Z
dc.date.issued 2018
dc.identifier.citation Román M, Caicoya M, Espinàs J, Sala M, Torá-Rocamora I, Quinta MJ. et al. Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain. Breast J. 2018 Jul;24(4):509-518. DOI: 10.1111/tbj.13003
dc.identifier.issn 1075-122X
dc.identifier.uri http://hdl.handle.net/10230/36493
dc.description.abstract Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof The Breast Journal. 2018 Jul;24(4):509-18
dc.rights This is the pre-peer reviewed version of the following article: Román M, Caicoya M, Espinàs J, Sala M, Torá-Rocamora I, Quinta MJ. et al. Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain. Breast J. 2018 Jul;24(4):509-518, which has been published in final form at http://dx.doi.org/10.1111/tbj.13003. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.subject.other Mama -- Malalties
dc.subject.other Mama -- Càncer
dc.title Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/tbj.13003
dc.subject.keyword Benign breast disease
dc.subject.keyword Breast neoplasm
dc.subject.keyword Prognostic factors
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking