dc.contributor.author | Román, Marta |
dc.contributor.author | Caicoya, Martin |
dc.contributor.author | Espinàs, Josep Alfons |
dc.contributor.author | Sala Serra, Maria |
dc.contributor.author | Torá Rocamora, Isabel, 1979- |
dc.contributor.author | Quinta, Maria J. |
dc.contributor.author | Vernet-Tomás, Maria |
dc.contributor.author | Saladié, Francina |
dc.contributor.author | Romero, Anabel |
dc.contributor.author | Sánchez, Mar |
dc.contributor.author | Baré, Marisa |
dc.contributor.author | Vidal, Carmen |
dc.contributor.author | Servitja Tormo, Sonia |
dc.contributor.author | Natal, Carmen |
dc.contributor.author | Corominas Torres, Josep Maria |
dc.contributor.author | Ferrer, Joana |
dc.contributor.author | Rodríguez Arana, Ana Maria |
dc.contributor.author | Castells, Xavier |
dc.contributor.author | BELE Study Group |
dc.date.accessioned | 2019-02-05T08:34:39Z |
dc.date.issued | 2018 |
dc.identifier.citation | Román M, Caicoya M, Espinàs J, Sala M, Torá-Rocamora I, Quinta MJ. et al. Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain. Breast J. 2018 Jul;24(4):509-518. DOI: 10.1111/tbj.13003 |
dc.identifier.issn | 1075-122X |
dc.identifier.uri | http://hdl.handle.net/10230/36493 |
dc.description.abstract | Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Wiley-Blackwell |
dc.relation.ispartof | The Breast Journal. 2018 Jul;24(4):509-18 |
dc.rights | This is the pre-peer reviewed version of the following article: Román M, Caicoya M, Espinàs J, Sala M, Torá-Rocamora I, Quinta MJ. et al. Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain. Breast J. 2018 Jul;24(4):509-518, which has been published in final form at http://dx.doi.org/10.1111/tbj.13003. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
dc.subject.other | Mama -- Malalties |
dc.subject.other | Mama -- Càncer |
dc.title | Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1111/tbj.13003 |
dc.subject.keyword | Benign breast disease |
dc.subject.keyword | Breast neoplasm |
dc.subject.keyword | Prognostic factors |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/acceptedVersion |