Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Román, Marta
• dc.contributor.author Caicoya, Martin
• dc.contributor.author Espinàs, Josep Alfons
• dc.contributor.author Sala Serra, Maria
• dc.contributor.author Torá Rocamora, Isabel, 1979-
• dc.contributor.author Quinta, Maria J.
• dc.contributor.author Vernet-Tomás, Maria
• dc.contributor.author Saladié, Francina
• dc.contributor.author Romero, Anabel
• dc.contributor.author Sánchez, Mar
• dc.contributor.author Baré, Marisa
• dc.contributor.author Vidal, Carmen
• dc.contributor.author Servitja Tormo, Sonia
• dc.contributor.author Natal, Carmen
• dc.contributor.author Corominas Torres, Josep Maria
• dc.contributor.author Ferrer, Joana
• dc.contributor.author Rodríguez Arana, Ana Maria
• dc.contributor.author Castells, Xavier
• dc.contributor.author BELE Study Group
• dc.date.accessioned 2019-02-05T08:34:39Z
• dc.date.issued 2018
• dc.description.abstract Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.
• dc.format.mimetype application/pdf
• dc.identifier.citation Román M, Caicoya M, Espinàs J, Sala M, Torá-Rocamora I, Quinta MJ. et al. Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain. Breast J. 2018 Jul;24(4):509-518. DOI: 10.1111/tbj.13003
• dc.identifier.doi http://dx.doi.org/10.1111/tbj.13003
• dc.identifier.issn 1075-122X
• dc.identifier.uri http://hdl.handle.net/10230/36493
• dc.language.iso eng
• dc.publisher Wiley-Blackwell
• dc.relation.ispartof The Breast Journal. 2018 Jul;24(4):509-18
• dc.rights This is the pre-peer reviewed version of the following article: Román M, Caicoya M, Espinàs J, Sala M, Torá-Rocamora I, Quinta MJ. et al. Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain. Breast J. 2018 Jul;24(4):509-518, which has been published in final form at http://dx.doi.org/10.1111/tbj.13003. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Benign breast disease
• dc.subject.keyword Breast neoplasm
• dc.subject.keyword Prognostic factors
• dc.subject.other Mama -- Malalties
• dc.subject.other Mama -- Càncer
• dc.title Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion