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Aortic and carotid intima-media thickness in term small-for-gestational-age newborns and relationship with prenatal signs of severity

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dc.contributor.author Stergiotou, Iosifina
dc.contributor.author Crispi Brillas, Fàtima
dc.contributor.author Valenzuela Alcaraz, Brenda
dc.contributor.author Cruz-Lemini, Mónica
dc.contributor.author Bijnens, Bart
dc.contributor.author Gratacós Solsona, Eduard
dc.date.accessioned 2018-11-29T11:11:22Z
dc.date.available 2018-11-29T11:11:22Z
dc.date.issued 2014
dc.identifier.citation Stergiotou I, Crispi F, Valenzuela-Alcaraz B, Cruz-Lemini M, Bijnens B, Gratacos E. Aortic and carotid intima-media thickness in term small-for-gestational-age newborns and relationship with prenatal signs of severity. Ultrasound Obstet Gynecol. 2014;43(6):625-31. DOI: 10.1002/uog.13245
dc.identifier.issn 0960-7692
dc.identifier.uri http://hdl.handle.net/10230/35888
dc.description.abstract Objective To assess carotid and aortic intima–media thickness (IMT) in term small‐for‐gestational‐age (SGA) newborns with and without prenatal signs of severity. Methods This prospective study comprised 67 cases diagnosed prenatally and 134 normally grown newborns. Cases were subclassified into SGA with no signs of severity and those with signs of severity, defined as a birth weight below the 3rd percentile or abnormal uterine artery Doppler or cerebroplacental ratio. Blood pressure and vascular IMT were evaluated. Results SGA newborns showed a non‐significant trend for higher values of blood pressure. IMT values were significantly increased in SGA newborns, with and without signs of severity, compared with controls. The magnitude of the increase was higher in SGA newborns with signs of severity. Conclusions Vascular IMT was increased in SGA newborns, irrespective of the presence or absence of prenatal signs of severity. This finding challenges the notion of ‘constitutionally small’ SGA, and supports the premise that the majority of SGA newborns have true growth restriction and suffer fetal cardiovascular programming.
dc.description.sponsorship This study was supported by grants from Instituto de Salud Carlos III and Ministerio de Economia y Competitividad (ref. PI11/00051, PI11/01709, PI12/00801 and SAF2012‐37196) cofinanciado por el Fondo Europeo de Desarrollo Regional de la Unión Europea ‘Una manera de hacer Europa’, Spain; Centro para el Desarrollo Técnico Industrial (Ref. cvREMOD 2009‐2012) apoyado por el Ministerio de Economia y Competitividad y Fondo de inversión local para el empleo, Spain; Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK) and Thrasher Research Fund (Salt Lake City, USA).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Ultrasound in Obstetrics and Gynecology. 2014;43(6):625-31.
dc.rights This is the pre-peer reviewed version of the following article: Stergiotou I, Crispi F, Valenzuela-Alcaraz B, Cruz-Lemini M, Bijnens B, Gratacos E. Aortic and carotid intima-media thickness in term small-for-gestational-age newborns and relationship with prenatal signs of severity. Ultrasound Obstet Gynecol. 2014;43(6):625-31., which has been published in final form at http://dx.doi.org/10.1002/uog.13245. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.title Aortic and carotid intima-media thickness in term small-for-gestational-age newborns and relationship with prenatal signs of severity
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/uog.13245
dc.subject.keyword Aortic intima–media thickness
dc.subject.keyword Blood pressure
dc.subject.keyword Carotid arterial intima–media thickness
dc.subject.keyword Late‐onset intrauterine growth restriction
dc.subject.keyword Small‐for‐gestational age
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012‐37196
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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