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Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial

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dc.contributor.author Sánchez-Rodriguez, Estefanía
dc.contributor.author Lima-Cabello, Elena
dc.contributor.author Biel-Glesson, Sara
dc.contributor.author Fernández-Navarro, Jose-Ramón
dc.contributor.author Calleja, Miguel Angel
dc.contributor.author Roca Bigorra, Maria
dc.contributor.author Espejo-Calvo, Juan A.
dc.contributor.author Gil-Extremera, Blas
dc.contributor.author Soria-Florido, Maria
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Alche, Juan de Dios
dc.contributor.author Martínez de Victoria, Emilio
dc.contributor.author Gil, Angel
dc.contributor.author Mesa, Maria-Dolores
dc.date.accessioned 2018-11-13T12:08:23Z
dc.date.available 2018-11-13T12:08:23Z
dc.date.issued 2018
dc.identifier.citation Sanchez-Rodriguez E, Lima-Cabello E, Biel-Glesson S, Fernandez-Navarro JR, Calleja MA, Roca M et al. Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial. Nutrients. 2018;10(5):e626. DOI: 10.3390/nu10050626
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/35741
dc.description.abstract The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Nutrients. 2018;10(5):e626
dc.rights © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu10050626
dc.subject.keyword Olive oil
dc.subject.keyword Virgin olive oil
dc.subject.keyword Olive oil polyphenols
dc.subject.keyword Maslinic acid
dc.subject.keyword Oleanolic acid
dc.subject.keyword Cardiovascular diseases
dc.subject.keyword Endothelial function
dc.subject.keyword Phenolic compounds
dc.subject.keyword Triterpenes
dc.subject.keyword Metabolic syndrome
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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