Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
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- dc.contributor.author Sánchez-Rodriguez, Estefanía
- dc.contributor.author Lima-Cabello, Elena
- dc.contributor.author Biel-Glesson, Sara
- dc.contributor.author Fernández-Navarro, Jose-Ramón
- dc.contributor.author Calleja, Miguel Angel
- dc.contributor.author Roca Bigorra, Maria
- dc.contributor.author Espejo-Calvo, Juan A.
- dc.contributor.author Gil-Extremera, Blas
- dc.contributor.author Soria-Florido, Maria
- dc.contributor.author Torre Fornell, Rafael de la
- dc.contributor.author Fitó Colomer, Montserrat
- dc.contributor.author Covas Planells, Maria Isabel
- dc.contributor.author Alche, Juan de Dios
- dc.contributor.author Martínez de Victoria, Emilio
- dc.contributor.author Gil, Angel
- dc.contributor.author Mesa, Maria-Dolores
- dc.date.accessioned 2018-11-13T12:08:23Z
- dc.date.available 2018-11-13T12:08:23Z
- dc.date.issued 2018
- dc.description.abstract The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).
- dc.format.mimetype application/pdf
- dc.identifier.citation Sanchez-Rodriguez E, Lima-Cabello E, Biel-Glesson S, Fernandez-Navarro JR, Calleja MA, Roca M et al. Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial. Nutrients. 2018;10(5):e626. DOI: 10.3390/nu10050626
- dc.identifier.doi http://dx.doi.org/10.3390/nu10050626
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/35741
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2018;10(5):e626
- dc.rights © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Olive oil
- dc.subject.keyword Virgin olive oil
- dc.subject.keyword Olive oil polyphenols
- dc.subject.keyword Maslinic acid
- dc.subject.keyword Oleanolic acid
- dc.subject.keyword Cardiovascular diseases
- dc.subject.keyword Endothelial function
- dc.subject.keyword Phenolic compounds
- dc.subject.keyword Triterpenes
- dc.subject.keyword Metabolic syndrome
- dc.title Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion