dc.contributor.author |
Lorenzo, Daniel |
dc.contributor.author |
Ochoa, María |
dc.contributor.author |
Piulats, Josep Maria |
dc.contributor.author |
Gutiérrez, Cristina |
dc.contributor.author |
Arias, Luis |
dc.contributor.author |
Català, Jaume |
dc.contributor.author |
Grau Magaña, Maria |
dc.contributor.author |
Peñafiel Muñoz, Judith |
dc.contributor.author |
Cobos, Estefanía |
dc.contributor.author |
Garcia-Bru, Pere |
dc.contributor.author |
Rubio, Marcos Javier |
dc.contributor.author |
Padrón-Pérez, Noel |
dc.contributor.author |
Dias, Bruno |
dc.contributor.author |
Pera, Joan |
dc.contributor.author |
Caminal, Josep Maria |
dc.date.accessioned |
2018-10-22T07:34:00Z |
dc.date.available |
2018-10-22T07:34:00Z |
dc.date.issued |
2017 |
dc.identifier.citation |
Lorenzo D, Ochoa M, Piulats JM, Gutiérrez C, Arias L, Català J. et al. Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanoma. Cancer Res Treat. 2018; 50(4): 1130-1139. DOI: 10.4143/crt.2017.171 |
dc.identifier.issn |
1598-2998 |
dc.identifier.uri |
http://hdl.handle.net/10230/35626 |
dc.description.abstract |
PURPOSE: The purpose of this study was to demonstrate the existence of a bimodal survival pattern in metastatic uveal melanoma. Secondary aims were to identify the characteristics and prognostic factors associated with long-term survival and to develop a clinical decision tree. MATERIALS AND METHODS: The medical records of 99 metastatic uveal melanoma patients were retrospectively reviewed. Patients were classified as either short (≤ 12 months) or long-term survivors (> 12 months) based on a graphical interpretation of the survival curve after diagnosis of the first metastatic lesion. Ophthalmic and oncological characteristicswere assessed in both groups. RESULTS: Of the 99 patients, 62 (62.6%) were classified as short-term survivors, and 37 (37.4%) as long-term survivors. The multivariate analysis identified the following predictors of long-term survival: age ≤ 65 years (p=0.012) and unaltered serum lactate dehydrogenase levels (p=0.018); additionally, the size (smaller vs. larger) of the largest liver metastasis showed a trend towards significance (p=0.063). Based on the variables significantly associated with long-term survival, we developed a decision tree to facilitate clinical decision-making. CONCLUSION: The findings of this study demonstrate the existence of a bimodal survival pattern in patients with metastatic uveal melanoma. The presence of certain clinical characteristics at diagnosis of distant disease is associated with long-term survival. A decision tree was developed to facilitate clinical decision-making and to counsel patients about the expected course of disease |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Korean Cancer Association |
dc.relation.ispartof |
Cancer Research and Treatment. 2018;50(4):1130-39 |
dc.rights |
Copyright ⓒ 2018 by the Korean Cancer Association. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc/3.0/ |
dc.subject.other |
Tumors |
dc.subject.other |
Melanoma |
dc.title |
Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanoma |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.4143/crt.2017.171 |
dc.subject.keyword |
Decision trees |
dc.subject.keyword |
Long-term survivors |
dc.subject.keyword |
Neoplasm metastasis |
dc.subject.keyword |
Uveal melanoma |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/acceptedVersion |