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Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanoma

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dc.contributor.author Lorenzo, Daniel
dc.contributor.author Ochoa, María
dc.contributor.author Piulats, Josep Maria
dc.contributor.author Gutiérrez, Cristina
dc.contributor.author Arias, Luis
dc.contributor.author Català, Jaume
dc.contributor.author Grau Magaña, Maria
dc.contributor.author Peñafiel Muñoz, Judith
dc.contributor.author Cobos, Estefanía
dc.contributor.author Garcia-Bru, Pere
dc.contributor.author Rubio, Marcos Javier
dc.contributor.author Padrón-Pérez, Noel
dc.contributor.author Dias, Bruno
dc.contributor.author Pera, Joan
dc.contributor.author Caminal, Josep Maria
dc.date.accessioned 2018-10-22T07:34:00Z
dc.date.available 2018-10-22T07:34:00Z
dc.date.issued 2017
dc.identifier.citation Lorenzo D, Ochoa M, Piulats JM, Gutiérrez C, Arias L, Català J. et al. Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanoma. Cancer Res Treat. 2018; 50(4): 1130-1139. DOI: 10.4143/crt.2017.171
dc.identifier.issn 1598-2998
dc.identifier.uri http://hdl.handle.net/10230/35626
dc.description.abstract PURPOSE: The purpose of this study was to demonstrate the existence of a bimodal survival pattern in metastatic uveal melanoma. Secondary aims were to identify the characteristics and prognostic factors associated with long-term survival and to develop a clinical decision tree. MATERIALS AND METHODS: The medical records of 99 metastatic uveal melanoma patients were retrospectively reviewed. Patients were classified as either short (≤ 12 months) or long-term survivors (> 12 months) based on a graphical interpretation of the survival curve after diagnosis of the first metastatic lesion. Ophthalmic and oncological characteristicswere assessed in both groups. RESULTS: Of the 99 patients, 62 (62.6%) were classified as short-term survivors, and 37 (37.4%) as long-term survivors. The multivariate analysis identified the following predictors of long-term survival: age ≤ 65 years (p=0.012) and unaltered serum lactate dehydrogenase levels (p=0.018); additionally, the size (smaller vs. larger) of the largest liver metastasis showed a trend towards significance (p=0.063). Based on the variables significantly associated with long-term survival, we developed a decision tree to facilitate clinical decision-making. CONCLUSION: The findings of this study demonstrate the existence of a bimodal survival pattern in patients with metastatic uveal melanoma. The presence of certain clinical characteristics at diagnosis of distant disease is associated with long-term survival. A decision tree was developed to facilitate clinical decision-making and to counsel patients about the expected course of disease
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Korean Cancer Association
dc.relation.ispartof Cancer Research and Treatment. 2018;50(4):1130-39
dc.rights Copyright ⓒ 2018 by the Korean Cancer Association. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
dc.subject.other Tumors
dc.subject.other Melanoma
dc.title Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanoma
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.4143/crt.2017.171
dc.subject.keyword Decision trees
dc.subject.keyword Long-term survivors
dc.subject.keyword Neoplasm metastasis
dc.subject.keyword Uveal melanoma
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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