Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanoma
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- dc.contributor.author Lorenzo, Danielca
- dc.contributor.author Ochoa, Maríaca
- dc.contributor.author Piulats, Josep Mariaca
- dc.contributor.author Gutiérrez, Cristinaca
- dc.contributor.author Arias, Luisca
- dc.contributor.author Català, Jaumeca
- dc.contributor.author Grau Magaña, Mariaca
- dc.contributor.author Peñafiel Muñoz, Judithca
- dc.contributor.author Cobos, Estefaníaca
- dc.contributor.author Garcia-Bru, Pereca
- dc.contributor.author Rubio, Marcos Javierca
- dc.contributor.author Padrón-Pérez, Noelca
- dc.contributor.author Dias, Brunoca
- dc.contributor.author Pera, Joanca
- dc.contributor.author Caminal, Josep Mariaca
- dc.date.accessioned 2018-10-22T07:34:00Z
- dc.date.available 2018-10-22T07:34:00Z
- dc.date.issued 2017
- dc.description.abstract PURPOSE: The purpose of this study was to demonstrate the existence of a bimodal survival pattern in metastatic uveal melanoma. Secondary aims were to identify the characteristics and prognostic factors associated with long-term survival and to develop a clinical decision tree. MATERIALS AND METHODS: The medical records of 99 metastatic uveal melanoma patients were retrospectively reviewed. Patients were classified as either short (≤ 12 months) or long-term survivors (> 12 months) based on a graphical interpretation of the survival curve after diagnosis of the first metastatic lesion. Ophthalmic and oncological characteristicswere assessed in both groups. RESULTS: Of the 99 patients, 62 (62.6%) were classified as short-term survivors, and 37 (37.4%) as long-term survivors. The multivariate analysis identified the following predictors of long-term survival: age ≤ 65 years (p=0.012) and unaltered serum lactate dehydrogenase levels (p=0.018); additionally, the size (smaller vs. larger) of the largest liver metastasis showed a trend towards significance (p=0.063). Based on the variables significantly associated with long-term survival, we developed a decision tree to facilitate clinical decision-making. CONCLUSION: The findings of this study demonstrate the existence of a bimodal survival pattern in patients with metastatic uveal melanoma. The presence of certain clinical characteristics at diagnosis of distant disease is associated with long-term survival. A decision tree was developed to facilitate clinical decision-making and to counsel patients about the expected course of disease
- dc.format.mimetype application/pdf
- dc.identifier.citation Lorenzo D, Ochoa M, Piulats JM, Gutiérrez C, Arias L, Català J. et al. Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanoma. Cancer Res Treat. 2018; 50(4): 1130-1139. DOI: 10.4143/crt.2017.171
- dc.identifier.doi http://dx.doi.org/10.4143/crt.2017.171
- dc.identifier.issn 1598-2998
- dc.identifier.uri http://hdl.handle.net/10230/35626
- dc.language.iso eng
- dc.publisher Korean Cancer Associationca
- dc.relation.ispartof Cancer Research and Treatment. 2018;50(4):1130-39
- dc.rights Copyright ⓒ 2018 by the Korean Cancer Association. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
- dc.subject.keyword Decision trees
- dc.subject.keyword Long-term survivors
- dc.subject.keyword Neoplasm metastasis
- dc.subject.keyword Uveal melanoma
- dc.subject.other Tumors
- dc.subject.other Melanoma
- dc.title Prognostic Factors and Decision Tree for Long-term Survival in Metastatic Uveal Melanomaca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion