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IKKα is required in the intestinal epithelial cells for tumour stemness

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dc.contributor.author Colomer Montañà, Carlota, 1990-
dc.contributor.author Margalef González, Pol, 1985-
dc.contributor.author González, Jessica
dc.contributor.author Vert, Anna
dc.contributor.author Bigas Salvans, Anna
dc.contributor.author Espinosa Blay, Lluís
dc.date.accessioned 2018-10-19T07:17:21Z
dc.date.issued 2018
dc.identifier.citation Colomer C, Margalef P, Gonzalez J, Vert A, Bigas A, Espinosa L. IKKα is required in the intestinal epithelial cells for tumour stemness. Br J Cancer. 2018 Mar 20;118(6):839-846. DOI: 10.1038/bjc.2017.459
dc.identifier.issn 0007-0920
dc.identifier.uri http://hdl.handle.net/10230/35623
dc.description.abstract BACKGROUND: Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. NF-κB signalling is a key element in cancer, mainly related to the activity of IKKβ. IKKα kinase also participates in this process by mechanisms that are primarily unknown. METHODS: We generated a compound mouse model with mutation in Apc and lacking intestinal epithelial IKKα, produced intestinal organoids and tumour spheroids with different genetic backgrounds, and performed immunohistochemistry and RNA-seq analysis. RESULTS: Deficiency of IKKα prevents adenoma formation, with adenomas lacking IKKα showing reduced proliferation. In contrast, IKKα status did not affect normal intestinal function. The same divergent phenotype was found in the organoid-spheroid model. We also found that epithelial IKKα controls stemness, proliferation and apoptosis-related expression. CONCLUSIONS: IKKα is a potential therapeutic target for Apc mutant colorectal cancer patients
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof British Journal of Cancer. 2018 Mar 20;118(6):839-46
dc.rights © Nature Publishing Group. http://dx.doi.org/ 10.1038/bjc.2017.459
dc.subject.other Còlon -- Càncer -- Aspectes genètics
dc.title IKKα is required in the intestinal epithelial cells for tumour stemness
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/ 10.1038/bjc.2017.459
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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