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Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain

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dc.contributor.author Albuixech Crespo, Beatriz
dc.contributor.author López Blanch, Laura
dc.contributor.author Burguera, Demián
dc.contributor.author Maeso, Ignacio
dc.contributor.author Sánchez Arrones, Luisa
dc.contributor.author Moreno Bravo, Juan Antonio
dc.contributor.author Somorjai, Ildikó Maureen Lara
dc.contributor.author Pascual Anaya, Juan
dc.contributor.author Puelles, Eduardo
dc.contributor.author Bovolenta, Paola
dc.contributor.author García Fernàndez, Jordi
dc.contributor.author Puelles, Luis
dc.contributor.author Irimia, Manuel
dc.contributor.author Ferrán, José Luis E.
dc.date.accessioned 2018-07-02T07:45:49Z
dc.date.available 2018-07-02T07:45:49Z
dc.date.issued 2017
dc.identifier.citation Albuixech-Crespo B, López-Blanch L, Burguera D, Maeso I, Sánchez-Arrones L, Moreno-Bravo JA et al. Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biol. 2017 Apr 19;15(4):e2001573. DOI: 10.1371/journal.pbio.2001573
dc.identifier.issn 1544-9173
dc.identifier.uri http://hdl.handle.net/10230/35010
dc.description.abstract All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.
dc.description.sponsorship Spanish Ministry of Economy and Competitiveness and European FEDER funds (grant number BFU2014-57516-P). To Luis Puelles and Jose Luis Ferran. European Research Council (grant number ERC-StG-LS2-637591). To Manuel Irimia. Spanish Ministry of Economy and Competitiveness (grant number SEV-2012-0208).Centro de Excelencia Severo Ochoa (to CRG, Manuel Irimia). Spanish Ministry of Economy and Competitiveness (grant number BFU2014-58908-P). To Jordi Garcia-Fernadez. Seneca Foundation, Comunidad de Murcia (grant number 19904/GERM/15). To Luis Puelles. Generalitat de Catalunya (grant number). ICREA Academia Prize to Jordi Garcia-Fernandez. Spanish Ministry of Economy and Competitiveness (grant number BFU2013-43213-P). To Paola Bovolenta. Spanish Ministry of Economy and Competitiveness (grant number BFU2014-55076-P). To Manuel Irimia. Including an FPI PhD fellowship to Laura Lopez-Blanch. Marine Alliance for Science and Technology Scotland (MASTS) (grant number). To Ildiko Somorjai.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS Biol. 2017 Apr 19;15(4):e2001573
dc.rights © 2017 Albuixech-Crespo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pbio.2001573
dc.subject.keyword Amphioxus
dc.subject.keyword Gene expression
dc.subject.keyword In situ hybridization
dc.subject.keyword Chick embryo
dc.subject.keyword Body patterning
dc.subject.keyword Neural tube
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/637591
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-57516-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-58908-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-43213-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55076-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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