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NF-κB Members Left Home: NF-κB-Independent Roles in Cancer

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dc.contributor.author Colomer Montañà, Carlota, 1990-
dc.contributor.author Marruecos, Laura
dc.contributor.author Vert, Anna
dc.contributor.author Bigas Salvans, Anna
dc.contributor.author Espinosa Blay, Lluís
dc.date.accessioned 2018-04-11T07:24:55Z
dc.date.available 2018-04-11T07:24:55Z
dc.date.issued 2017
dc.identifier.citation Colomer C, Marruecos L, Vert A, Bigas A, Espinosa L. NF-κB Members Left Home: NF-κB-Independent Roles in Cancer. Biomedicines. 2017 May 25;5(2). pii: E26. DOI: 10.3390/biomedicines5020026
dc.identifier.issn 2227-9059
dc.identifier.uri http://hdl.handle.net/10230/34331
dc.description.abstract Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-κB members in NF-κB unrelated pathways provided novel attractive targets for cancer therapy, specifically linked to particular pathologic responses. Here we review specific functions of IκB kinase complexes (IKKs) and IκBs, which have distinctly tumor promoting or suppressing activities in cancer. Understanding how these proteins are regulated in a tumor-related context will provide new opportunities for drug development.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Càncer
dc.subject.other Proteïnes
dc.title NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/biomedicines5020026
dc.subject.keyword Cancer
dc.subject.keyword IKKs
dc.subject.keyword IκBs
dc.subject.keyword NF-κB
dc.subject.keyword Non-conventional pathways
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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