NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
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- dc.contributor.author Colomer Montañà, Carlota, 1990-ca
- dc.contributor.author Marruecos, Lauraca
- dc.contributor.author Vert, Annaca
- dc.contributor.author Bigas Salvans, Annaca
- dc.contributor.author Espinosa Blay, Lluísca
- dc.date.accessioned 2018-04-11T07:24:55Z
- dc.date.available 2018-04-11T07:24:55Z
- dc.date.issued 2017
- dc.description.abstract Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-κB members in NF-κB unrelated pathways provided novel attractive targets for cancer therapy, specifically linked to particular pathologic responses. Here we review specific functions of IκB kinase complexes (IKKs) and IκBs, which have distinctly tumor promoting or suppressing activities in cancer. Understanding how these proteins are regulated in a tumor-related context will provide new opportunities for drug development.
- dc.format.mimetype application/pdf
- dc.identifier.citation Colomer C, Marruecos L, Vert A, Bigas A, Espinosa L. NF-κB Members Left Home: NF-κB-Independent Roles in Cancer. Biomedicines. 2017 May 25;5(2). pii: E26. DOI: 10.3390/biomedicines5020026
- dc.identifier.doi http://dx.doi.org/10.3390/biomedicines5020026
- dc.identifier.issn 2227-9059
- dc.identifier.uri http://hdl.handle.net/10230/34331
- dc.language.iso eng
- dc.publisher MDPIca
- dc.rights Copyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cancer
- dc.subject.keyword IKKs
- dc.subject.keyword IκBs
- dc.subject.keyword NF-κB
- dc.subject.keyword Non-conventional pathways
- dc.subject.other Càncer
- dc.subject.other Proteïnes
- dc.title NF-κB Members Left Home: NF-κB-Independent Roles in Cancerca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion