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Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication

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dc.contributor.author Haijen, Eline
dc.contributor.author Farré Albaladejo, Magí
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Pastor, Antonio
dc.contributor.author Olesti Muñoz, Eulàlia
dc.contributor.author Pizarro Lozano, Mª Nieves
dc.contributor.author Ramaekers, Johannes G.
dc.contributor.author Kuypers, Kim PC
dc.date.accessioned 2018-03-22T08:44:30Z
dc.date.available 2018-03-22T08:44:30Z
dc.date.issued 2018
dc.identifier.citation Haijen E, Farre M, de la Torre R, Pastor A, Olesti E, Pizarro N et al. Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication. Psychopharmacology (Berl). 2018 Mar;235(3):709-717. DOI: 10.1007/s00213-017-4787-2. Epub 2017 Nov 16
dc.identifier.issn 0033-3158
dc.identifier.uri http://hdl.handle.net/10230/34238
dc.description.abstract BACKGROUND: Preclinical data have suggested involvement of the endocannabinoid (eCB) system in MDMA-induced memory impairment. Clinical research has shown that blockade of the 5-HT2 receptor nulls memory impairment during MDMA intoxication. Interestingly, studies have demonstrated that the eCB and the 5-HT system interact. It was hypothesized that MDMA would cause an increase in eCB concentrations together with a decrease in memory performance, and that combining MDMA with a 5-HT2 receptor blocker ketanserin would lead to a counteraction of the MDMA effects on eCB concentrations and memory. METHODS: Twenty healthy recreational polydrug users entered a double-blind placebo-controlled within-subject study. Participants received a pre-treatment (ketanserin 40 mg, placebo) followed 30 min later by a treatment (MDMA 75 mg, placebo). Verbal memory was tested by means of a 30-word learning test. Endocannabinoid concentrations (anandamide (2-AG); N-arachidonylethanolamine (AEA)) were assessed in blood at baseline, before (90 min post-treatment) and after cognitive tests (150 min post-treatment). RESULTS: Findings showed that MDMA impaired memory 90 min post-treatment in the word learning task. This effect was a replication of previous studies using the same dose of MDMA (75 mg) and the same learning paradigm. Contrary to our hypothesis, MDMA did not affect eCB concentrations, nor did ketanserin block MDMA-induced memory impairment. Ketanserin caused an increase in AEA concentrations, 180 min after administration. CONCLUSION: Current findings suggest that peripherally measured endocannabinoids are not associated with the verbal memory deficit during MDMA intoxication. TRIAL REGISTRATION NUMBER: NTR3691.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Psychopharmacology (Berl). 2018 Mar;235(3):709-717
dc.rights © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00213-017-4787-2
dc.subject.keyword 2-AG
dc.subject.keyword 5-HT2 receptor
dc.subject.keyword AEA
dc.subject.keyword Endocannabinoids
dc.subject.keyword Ketanserin
dc.subject.keyword MDMA
dc.subject.keyword Verbal memory
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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