Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication
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- dc.contributor.author Haijen, Elineca
- dc.contributor.author Farré Albaladejo, Magíca
- dc.contributor.author Torre Fornell, Rafael de laca
- dc.contributor.author Pastor, Antonioca
- dc.contributor.author Olesti Muñoz, Eulàlia, 1991-ca
- dc.contributor.author Pizarro Lozano, Mª Nievesca
- dc.contributor.author Ramaekers, Johannes G.ca
- dc.contributor.author Kuypers, Kim PCca
- dc.date.accessioned 2018-03-22T08:44:30Z
- dc.date.available 2018-03-22T08:44:30Z
- dc.date.issued 2018
- dc.description.abstract BACKGROUND: Preclinical data have suggested involvement of the endocannabinoid (eCB) system in MDMA-induced memory impairment. Clinical research has shown that blockade of the 5-HT2 receptor nulls memory impairment during MDMA intoxication. Interestingly, studies have demonstrated that the eCB and the 5-HT system interact. It was hypothesized that MDMA would cause an increase in eCB concentrations together with a decrease in memory performance, and that combining MDMA with a 5-HT2 receptor blocker ketanserin would lead to a counteraction of the MDMA effects on eCB concentrations and memory. METHODS: Twenty healthy recreational polydrug users entered a double-blind placebo-controlled within-subject study. Participants received a pre-treatment (ketanserin 40 mg, placebo) followed 30 min later by a treatment (MDMA 75 mg, placebo). Verbal memory was tested by means of a 30-word learning test. Endocannabinoid concentrations (anandamide (2-AG); N-arachidonylethanolamine (AEA)) were assessed in blood at baseline, before (90 min post-treatment) and after cognitive tests (150 min post-treatment). RESULTS: Findings showed that MDMA impaired memory 90 min post-treatment in the word learning task. This effect was a replication of previous studies using the same dose of MDMA (75 mg) and the same learning paradigm. Contrary to our hypothesis, MDMA did not affect eCB concentrations, nor did ketanserin block MDMA-induced memory impairment. Ketanserin caused an increase in AEA concentrations, 180 min after administration. CONCLUSION: Current findings suggest that peripherally measured endocannabinoids are not associated with the verbal memory deficit during MDMA intoxication. TRIAL REGISTRATION NUMBER: NTR3691.
- dc.format.mimetype application/pdf
- dc.identifier.citation Haijen E, Farre M, de la Torre R, Pastor A, Olesti E, Pizarro N et al. Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication. Psychopharmacology (Berl). 2018 Mar;235(3):709-17. DOI: 10.1007/s00213-017-4787-2
- dc.identifier.doi http://dx.doi.org/10.1007/s00213-017-4787-2
- dc.identifier.issn 0033-3158
- dc.identifier.uri http://hdl.handle.net/10230/34238
- dc.language.iso eng
- dc.publisher Springerca
- dc.relation.ispartof Psychopharmacology (Berl). 2018 Mar;235(3):709-17
- dc.rights © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword 2-AG
- dc.subject.keyword 5-HT2 receptor
- dc.subject.keyword AEA
- dc.subject.keyword Endocannabinoids
- dc.subject.keyword Ketanserin
- dc.subject.keyword MDMA
- dc.subject.keyword Verbal memory
- dc.title Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxicationca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion