Welcome to the UPF Digital Repository

Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis

Show simple item record

dc.contributor.author Fröhlich, Matthias
dc.contributor.author Pinart, Mariona
dc.contributor.author Keller, Theresa
dc.contributor.author Reich, Andreas
dc.contributor.author Cabieses, Báltica
dc.contributor.author Hohmann, Cynthia
dc.contributor.author Postma, Dirkje S.
dc.contributor.author Bousquet, Jean
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Keil, Thomas
dc.contributor.author Roll, Stephanie
dc.date.accessioned 2018-02-26T15:14:08Z
dc.date.available 2018-02-26T15:14:08Z
dc.date.issued 2017
dc.identifier.citation Fröhlich M, Pinart M, Keller T, Reich A, Cabieses B, Hohmann C et al. Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis. Clin Transl Allergy. 2017 Dec 5;7:44. DOI: 10.1186/s13601-017-0176-5
dc.identifier.issn 2045-7022
dc.identifier.uri http://hdl.handle.net/10230/34006
dc.description.abstract BACKGROUND: Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specific differences in the prevalence of coexisting allergic rhinitis and asthma in childhood, adolescence and adulthood. METHODS: Post-hoc analysis of systematic review with meta-analysis concerning sex-specific prevalence of allergic rhinitis. Using random-effects meta-analysis, we assessed male-female ratios for coexisting allergic rhinitis and asthma in children (0-10 years), adolescents (11-17) and adults (> 17). Electronic searches were performed using MEDLINE and EMBASE for the time period 2000-2014. We included population-based observational studies, reporting coexisting allergic rhinitis and asthma as outcome stratified by sex. We excluded non-original or non-population-based studies, studies with only male or female participants or selective patient collectives. RESULTS: From a total of 6539 citations, 10 studies with a total of 93,483 participants met the inclusion criteria. The male-female ratios (95% CI) for coexisting allergic rhinitis and asthma were 1.65 (1.52; 1.78) in children (N = 6 studies), 0.61 (0.51; 0.72) in adolescents (N = 2) and 1.03 (0.79; 1.35) in adults (N = 2). Male-female ratios for allergic rhinitis only were 1.25 (1.19; 1.32, N = 5) in children, 0.80 (0.71; 0.89, N = 2) in adolescents and 0.98 (0.74; 1.30, N = 2) in adults, respectively. CONCLUSIONS: The prevalence of coexisting allergic rhinitis and asthma shows a clear male predominance in childhood and seems to switch to a female predominance in adolescents. This switch was less pronounced for allergic rhinitis only.
dc.description.sponsorship Mariona Pinart is a recipient of a 'Sara Borrell' postdoctoral contract (CD11/00090) from the Fondo de Investigaciones Sanitarias (FIS), Ministry of Economy and Competitiveness, Spain. This work was initiated and supported by MeDALL, a collaborative project conducted within the European Union under the Health Cooperation Work Programme of the 7th Framework Programme (Grant Agreement No. 261357).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof Clinical and Translational Allergy. 2017 Dec 5;7:44
dc.rights © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s13601-017-0176-5
dc.subject.keyword Allergic rhinitis
dc.subject.keyword Asthma
dc.subject.keyword Multimorbidity
dc.subject.keyword Prevalence
dc.subject.keyword Systematic review
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


In collaboration with Compliant to Partaking