Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis

Fröhlich, Matthias; Pinart, Mariona; Keller, Theresa; Reich, Andreas; Cabieses, Báltica; Hohmann, Cynthia; Postma, Dirkje S.; Bousquet, Jean; Antó i Boqué, Josep Maria; Keil, Thomas; Roll, Stephanie

Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis

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dc.contributor.author Fröhlich, Matthiasca
dc.contributor.author Pinart, Marionaca
dc.contributor.author Keller, Theresaca
dc.contributor.author Reich, Andreasca
dc.contributor.author Cabieses, Bálticaca
dc.contributor.author Hohmann, Cynthiaca
dc.contributor.author Postma, Dirkje S.ca
dc.contributor.author Bousquet, Jeanca
dc.contributor.author Antó i Boqué, Josep Mariaca
dc.contributor.author Keil, Thomasca
dc.contributor.author Roll, Stephanieca
dc.date.accessioned 2018-02-26T15:14:08Z
dc.date.available 2018-02-26T15:14:08Z
dc.date.issued 2017
dc.description.abstract BACKGROUND: Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specific differences in the prevalence of coexisting allergic rhinitis and asthma in childhood, adolescence and adulthood. METHODS: Post-hoc analysis of systematic review with meta-analysis concerning sex-specific prevalence of allergic rhinitis. Using random-effects meta-analysis, we assessed male-female ratios for coexisting allergic rhinitis and asthma in children (0-10 years), adolescents (11-17) and adults (> 17). Electronic searches were performed using MEDLINE and EMBASE for the time period 2000-2014. We included population-based observational studies, reporting coexisting allergic rhinitis and asthma as outcome stratified by sex. We excluded non-original or non-population-based studies, studies with only male or female participants or selective patient collectives. RESULTS: From a total of 6539 citations, 10 studies with a total of 93,483 participants met the inclusion criteria. The male-female ratios (95% CI) for coexisting allergic rhinitis and asthma were 1.65 (1.52; 1.78) in children (N = 6 studies), 0.61 (0.51; 0.72) in adolescents (N = 2) and 1.03 (0.79; 1.35) in adults (N = 2). Male-female ratios for allergic rhinitis only were 1.25 (1.19; 1.32, N = 5) in children, 0.80 (0.71; 0.89, N = 2) in adolescents and 0.98 (0.74; 1.30, N = 2) in adults, respectively. CONCLUSIONS: The prevalence of coexisting allergic rhinitis and asthma shows a clear male predominance in childhood and seems to switch to a female predominance in adolescents. This switch was less pronounced for allergic rhinitis only.
dc.description.sponsorship Mariona Pinart is a recipient of a 'Sara Borrell' postdoctoral contract (CD11/00090) from the Fondo de Investigaciones Sanitarias (FIS), Ministry of Economy and Competitiveness, Spain. This work was initiated and supported by MeDALL, a collaborative project conducted within the European Union under the Health Cooperation Work Programme of the 7th Framework Programme (Grant Agreement No. 261357).
dc.format.mimetype application/pdf
dc.identifier.citation Fröhlich M, Pinart M, Keller T, Reich A, Cabieses B, Hohmann C et al. Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis. Clin Transl Allergy. 2017 Dec 5;7:44. DOI: 10.1186/s13601-017-0176-5
dc.identifier.doi http://dx.doi.org/10.1186/s13601-017-0176-5
dc.identifier.issn 2045-7022
dc.identifier.uri http://hdl.handle.net/10230/34006
dc.language.iso eng
dc.publisher BioMed Centralca
dc.relation.ispartof Clinical and Translational Allergy. 2017 Dec 5;7:44
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Allergic rhinitis
dc.subject.keyword Asthma
dc.subject.keyword Multimorbidity
dc.subject.keyword Prevalence
dc.subject.keyword Systematic review
dc.title Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysisca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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