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Avoiding neuromuscular stimulation in liver irreversible electroporation using radiofrequency electric fields

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dc.contributor.author Castellví Fernández, Quim
dc.contributor.author Mercadal, Borja
dc.contributor.author Moll, Xavier
dc.contributor.author Fondevila, Dolors
dc.contributor.author Andaluz, Anna
dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.date.accessioned 2017-12-18T18:19:06Z
dc.date.issued 2018
dc.identifier.citation Castellví Q, Mercadal B, Moll X, Fondevila D, Andaluz A, Ivorra A. Avoiding neuromuscular stimulation in liver irreversible electroporation using radiofrequency electric fields. Phys Med Biol. 2018 Jan;63(3):[18 p.]. DOI: 10.1088/1361-6560/aaa16f
dc.identifier.issn 0031-9155
dc.identifier.uri http://hdl.handle.net/10230/33526
dc.description.abstract Electroporation based treatments typically consist in applying high voltage dc pulses. As an undesired side effect, these dc pulses cause electrical stimulation of excitable tissues such as motor nerves. In the present in vivo study, it was explored the use of bursts of sinusoidal voltage in the frequency range from 50 kHz to 2 MHz to induce irreversible electroporation (IRE) whilst avoiding neuromuscular stimulation. Series of 100 dc pulses or sinusoidal bursts, both with an individual duration of 100 μs, were delivered to rabbit liver through thin needles in a monopolar electrode configuration and thoracic movements were recorded with an accelerometer. Tissue samples were harvested three hours after treatment and later postprocessed to determine the dimensions of the IRE lesions. Thermal damage due to Joule heating was ruled out via computer simulations. Sinusoidal bursts with a frequency equal or above 100 kHz did not cause thoracic movements and induced lesions equivalent to those obtained with conventional dc pulses when the applied voltage amplitude was sufficiently high. IRE efficacy dropped with increasing frequency. For 100 kHz bursts, it was estimated that the electric field threshold for IRE is about 1.4 kV/cm whereas that of dc pulses is about 0.5 kV/cm.
dc.description.sponsorship This work was supported by the Ministry of Economy and Competitiveness of Spain through the grant TEC2014-52383-C3-R (TEC2014-52383-C3-2-R and TEC2014-52383-C3-3-R).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Institute of Physics (IOP)
dc.relation.ispartof Physics in Medicine and Biology. 2018 Jan;63(3):[18 p.].
dc.rights © Institute of Physics (IOP) (http://dx.doi.org/10.1088/1361-6560/aaa16f)
dc.title Avoiding neuromuscular stimulation in liver irreversible electroporation using radiofrequency electric fields
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1088/1361-6560/aaa16f
dc.subject.keyword Electroporation
dc.subject.keyword Irreversible electroporation
dc.subject.keyword Ablation
dc.subject.keyword Radiofrequency electric fields
dc.subject.keyword Sinusoidal voltages
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PN/TEC2014-52383-C3-2-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PN/TEC2014-52383-C3-3-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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