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MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis

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dc.contributor.author Fernández Rodríguez, M. Concepción
dc.contributor.author Bellosillo Paricio, Beatriz
dc.contributor.author Ferraro Rosset, Mariana Paola
dc.contributor.author Seoane, Agustín
dc.contributor.author Sanchez Gonzalez, Blanca
dc.contributor.author Pairet García, Silvia
dc.contributor.author Pons, A.
dc.contributor.author Barranco Sanz, Luis Carlos
dc.contributor.author Vela Ortíz, María del Carmen
dc.contributor.author Gimeno Vázquez, Eva
dc.contributor.author Colomo Saperas, Luis Alberto
dc.contributor.author Besses Raebel, Carles
dc.contributor.author Navarro, Alfons
dc.contributor.author Salar Silvestre, Antonio
dc.date.accessioned 2017-12-01T08:20:20Z
dc.date.available 2017-12-01T08:20:20Z
dc.date.issued 2017
dc.identifier.citation Fernández C, Bellosillo B, Ferraro M, Seoane A, Sánchez-González B, Pairet S et al. MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis. Cancer Genomics Proteomics. 2017 Jan 2;14(1):75-82. DOI: 10.21873/cgp.20020
dc.identifier.issn 1109-6535
dc.identifier.uri http://hdl.handle.net/10230/33425
dc.description.abstract BACKGROUND: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic gastritis. MicroRNAs are deregulated in lymphomas, but their role and usefulness in gastric MALT lymphoma has not been extensively investigated. MATERIALS AND METHODS: We analyzed the expression of 384 miRNAs using TaqMan microRNA assay in a training series of 10 gastric MALT lymphomas, 3 chronic gastritis and 2 reactive lymph nodes. Then, significantly deregulated miRNAs were individually assessed by real-time PCR in a validation series of 16 gastric MALT lymphomas and 12 chronic gastritis. RESULTS: Gastric MALT lymphoma is characterized by a specific miRNA expression profile. Among the differentially expressed miRNAs, a significant overexpression of miR-142-3p and miR-155 and down-regulation of miR-203 was observed in gastric MALT lymphoma when compared to chronic gastritis. CONCLUSION: miR-142-3p, miR-155 and miR-203 expression levels might be helpful biomarkers for the differential diagnosis between gastric MALT lymphomas and chronic gastritis.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher International Institute of Anticancer Research (IIAR)
dc.relation.ispartof Cancer Genomics and Proteomics. 2017 Jan 2;14(1):75-82
dc.rights © 2017, by The International Institute of Anticancer Research
dc.subject.other Limfomes
dc.subject.other Estómac -- Inflamació
dc.title MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.21873/cgp.20020
dc.subject.keyword MicroRNAs
dc.subject.keyword Chronic gastritis
dc.subject.keyword Gastric MALT lymphoma
dc.subject.keyword miR-155
dc.subject.keyword miR-203
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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