MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis

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• dc.contributor.author Fernández Rodríguez, M. Concepciónca
• dc.contributor.author Bellosillo Paricio, Beatrizca
• dc.contributor.author Ferraro Rosset, Mariana Paolaca
• dc.contributor.author Seoane, Agustínca
• dc.contributor.author Sanchez Gonzalez, Blancaca
• dc.contributor.author Pairet García, Silviaca
• dc.contributor.author Pons, A.ca
• dc.contributor.author Barranco Sanz, Luis Carlosca
• dc.contributor.author Vela Ortíz, María del Carmenca
• dc.contributor.author Gimeno Vázquez, Evaca
• dc.contributor.author Colomo Saperas, Luis Albertoca
• dc.contributor.author Besses Raebel, Carlesca
• dc.contributor.author Navarro, Alfonsca
• dc.contributor.author Salar Silvestre, Antonioca
• dc.date.accessioned 2017-12-01T08:20:20Z
• dc.date.available 2017-12-01T08:20:20Z
• dc.date.issued 2017
• dc.description.abstract BACKGROUND: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic gastritis. MicroRNAs are deregulated in lymphomas, but their role and usefulness in gastric MALT lymphoma has not been extensively investigated. MATERIALS AND METHODS: We analyzed the expression of 384 miRNAs using TaqMan microRNA assay in a training series of 10 gastric MALT lymphomas, 3 chronic gastritis and 2 reactive lymph nodes. Then, significantly deregulated miRNAs were individually assessed by real-time PCR in a validation series of 16 gastric MALT lymphomas and 12 chronic gastritis. RESULTS: Gastric MALT lymphoma is characterized by a specific miRNA expression profile. Among the differentially expressed miRNAs, a significant overexpression of miR-142-3p and miR-155 and down-regulation of miR-203 was observed in gastric MALT lymphoma when compared to chronic gastritis. CONCLUSION: miR-142-3p, miR-155 and miR-203 expression levels might be helpful biomarkers for the differential diagnosis between gastric MALT lymphomas and chronic gastritis.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Fernández C, Bellosillo B, Ferraro M, Seoane A, Sánchez-González B, Pairet S et al. MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis. Cancer Genomics Proteomics. 2017 Jan 2;14(1):75-82. DOI: 10.21873/cgp.20020
• dc.identifier.doi http://dx.doi.org/10.21873/cgp.20020
• dc.identifier.issn 1109-6535
• dc.identifier.uri http://hdl.handle.net/10230/33425
• dc.language.iso eng
• dc.publisher International Institute of Anticancer Research (IIAR)ca
• dc.relation.ispartof Cancer Genomics and Proteomics. 2017 Jan 2;14(1):75-82
• dc.rights © 2017, by The International Institute of Anticancer Research
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword MicroRNAs
• dc.subject.keyword Chronic gastritis
• dc.subject.keyword Gastric MALT lymphoma
• dc.subject.keyword miR-155
• dc.subject.keyword miR-203
• dc.subject.other Limfomes
• dc.subject.other Estómac -- Inflamació
• dc.title MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritisca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion