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Avoiding nerve stimulation in irreversible electroporation: a numerical modeling study

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dc.contributor.author Mercadal Cavaller, Borja
dc.contributor.author Arena, Christopher B.
dc.contributor.author Davalos, Rafael V.
dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.date.accessioned 2017-09-15T12:49:22Z
dc.date.issued 2017
dc.identifier.citation Mercadal B, Arena CB, Davalos RV, Ivorra A. Avoiding nerve stimulation in irreversible electroporation: a numerical modeling study. Physics in medicine and biology. 2017;62(20):8060-79.. DOI: 10.1088/1361-6560/aa8c53
dc.identifier.issn 0031-9155
dc.identifier.uri http://hdl.handle.net/10230/32767
dc.description.abstract Electroporation based treatments consist in applying one or multiple high voltage pulses to the tissues to be treated. As an undesired side effect, these pulses cause electrical stimulation of excitable tissues such as nerves and muscles. This increases the complexity of the treatments and may pose a risk to the patient. To minimize electrical stimulation during electroporation based treatments, it has been proposed to replace the commonly used monopolar pulses by bursts of short bipolar pulses. In the present study, we have numerically analyzed the rationale for such approach. We have compared different pulsing protocols in terms of their electroporation efficacy and their capability to trigger action potentials in nerves. For that, we have developed a modeling framework that combines numerical models of nerve fibers and experimental data on irreversible electroporation. Our results indicate that, by replacing the conventional relatively long monopolar pulses by bursts of short bipolar pulses, it is possible to ablate a large tissue region without triggering action potentials in a nearby nerve. Our models indicate that this is possible because, as the pulse length of these bipolar pulses is reduced, the stimulation thresholds raise faster than the irreversible electroporation thresholds. We propose that this different dependence on the pulse length is due to the fact that transmembrane charging for nerve fibers is much slower than that of cells treated by electroporation because of their geometrical differences.
dc.description.sponsorship This work was supported by the Ministry of Economy and Competitiveness of Spain through the grant TEC2014-52383-C3-2-R. RVD’s research is supported by the National Institutes of Health under award number NIH 1R21 CA192041-01.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Institute of Physics (IOP)
dc.relation.ispartof Physics in medicine and biology. 2017;62(20):8060-79.
dc.rights © Institute of Physics (IOP) http://iopscience.iop.org/article/10.1088/1361-6560/aa8c53 This document is under a CC BY-NC-ND 3.0 licence after a 12 month embargo period.
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.title Avoiding nerve stimulation in irreversible electroporation: a numerical modeling study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1088/1361-6560/aa8c53
dc.subject.keyword Electroporation
dc.subject.keyword Irreversible electroporation
dc.subject.keyword Nerve stimulation
dc.subject.keyword Muscle contractions
dc.subject.keyword Bipolar pulses
dc.subject.keyword H-FIRE
dc.subject.keyword Ablation
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014-52383-C3-2-R
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2018-09-17
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2018-09-17

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