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Modeling liver electrical conductivity during hypertonic injection

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dc.contributor.author Castellví Fernández, Quim
dc.contributor.author Sánchez Velázquez, Patricia, 1985-
dc.contributor.author Moll, Xavier
dc.contributor.author Berjano, Enrique J.
dc.contributor.author Andaluz, Anna
dc.contributor.author Burdío Pinilla, Fernando
dc.contributor.author Bijnens, Bart
dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.date.accessioned 2017-06-06T14:01:33Z
dc.date.available 2017-06-06T14:01:33Z
dc.date.issued 2018
dc.identifier.citation Castellví Q, Sánchez-Velázquez P, Moll X, Berjano E, Andaluz A, Burdío F, Bijnens B, Ivorra A. Modeling liver electrical conductivity during hypertonic injection. Int J Numer Method Biomed Eng. 2018;34(1): e2904. DOI: 10.1002/cnm.2904
dc.identifier.issn 2040-7947
dc.identifier.uri http://hdl.handle.net/10230/32236
dc.description.abstract Metastases in the liver frequently grow as scattered tumor nodules which neither can be removed by surgical resection nor focally ablated. Previously, we have proposed a novel technique based on irreversible electroporation which may be able to simultaneously treat all nodules in the liver while sparing healthy tissue. The proposed technique requires increasing the electrical conductivity of healthy liver by injecting a hypersaline solution through the portal vein. Aiming to assess the capability of increasing the global conductivity of the liver by means of hypersaline fluids, here it is presented a mathematical model which estimates the NaCl distribution within the liver and the resulting conductivity change. The model fuses wellestablished compartmental pharmacokinetic models of the organ with saline injection models employed for resuscitation treatments and it considers changes in sinusoidal blood viscosity due to the hypertonicity of the solution. Here it is also described a pilot experimental study in pigs in which different volumes of NaCl 20% (from 100 to 200 ml) were injected through the portal vein at different flow rates (from 53 to 171 ml/min). The in vivo conductivity results fit those obtained by the model, both quantitatively and qualitatively, being able to predict the maximum conductivity with a 14.6% average relative error. The maximum conductivity value was 0.44 S/m which corresponds to increasing four times the mean basal conductivity (0.11 S/m). The results suggest that the presented model is well suited for predicting on liver conductivity changes during hypertonic saline injection.
dc.description.sponsorship Spanish Government; contract/grant number: TEC2014-52383-C3-1-R, TEC2014-52383-C3-2-R and TEC2014-52383-C3-3-R
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof International Journal for Numerical Methods in Biomedical Engineering. 2018;34(1): e2904.
dc.rights This is the peer reviewed version of the following article: Castellví Q, Sánchez-Velázquez P, Moll X, Berjano E, Andaluz A, Burdío F, Bijnens B, Ivorra A. Modeling Liver Electrical Conductivity during Hypertonic Injection. Int. J. Numer. Meth. Biomed. Engng. 2017:e02904, which has been published in final form at http://dx.doi.org/10.1002/cnm.2904 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.title Modeling liver electrical conductivity during hypertonic injection
dc.type info:eu-repo/semantics/conferenceObject
dc.identifier.doi http://dx.doi.org/10.1002/cnm.2904
dc.subject.keyword Numerical modelling of organs
dc.subject.keyword Liver
dc.subject.keyword Hypertonic solutions
dc.subject.keyword Bioimpedance
dc.subject.keyword Electroporation
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014-52383-C3-1-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014-52383-C3-2-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014-52383-C3-3-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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