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Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome

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dc.contributor.author Catuara Solarz, Silvina, 1986-
dc.contributor.author Espinosa-Carrasco, José
dc.contributor.author Erb, Ionas
dc.contributor.author Langohr, Klaus
dc.contributor.author Gonzalez, Juan Ramon
dc.contributor.author Notredame, Cedric
dc.contributor.author Dierssen, Mara
dc.date.accessioned 2017-04-24T10:29:47Z
dc.date.available 2017-04-24T10:29:47Z
dc.date.issued 2016
dc.identifier.citation Catuara-Solarz S, Espinosa-Carrasco J, Erb I, Langohr K, Gonzalez JR, Notredame C et al. Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome. eNeuro. 2016;3(5):ENEURO.0103-16.2016. DOI: 10.1523/ENEURO.0103-16.2016
dc.identifier.issn 2373-2822
dc.identifier.uri http://hdl.handle.net/10230/30883
dc.description.abstract Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown. Here, we explored the effects of a combined therapy with environmental enrichment (EE) and EGCG in the Ts65Dn mouse model of DS at young age. Our results show that combined EE-EGCG treatment improved corticohippocampal-dependent learning and memory. Cognitive improvements were accompanied by a rescue of cornu ammonis 1 (CA1) dendritic spine density and a normalization of the proportion of excitatory and inhibitory synaptic markers in CA1 and dentate gyrus.
dc.description.sponsorship This research was supported by DIUE of Generalitat de Catalunya (Grups consolidats SGR 2014/1125); Fondation Jérôme Lejeune (Paris, France); Spanish Ministry of Economy and Finance (MINECO) grants SAF2013-49129-C2-1-R, BFU2011-28575, and MTM2015-64465-C2-1-R CDTI (“Smartfoods”); the CIBER of Rare Diseases (ISCIII initiative); and EU-Era Net Neuron PCIN-2013-060. The CRG has received support as a Severo Ochoa Center of Excellence SEV- 2012-O208. S.C.-S. received a FPI doctoral Fellowship from the MINECO (SAF2010-16427).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Society for Neuroscience
dc.relation.ispartof eNeuro. 2016;3(5):ENEURO.0103-16.2016
dc.rights Copyright © 2016 Catuara-Solarz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1523/ENEURO.0103-16.2016
dc.subject.keyword (-)-Epigallocatechin-3-gallate
dc.subject.keyword Down syndrome
dc.subject.keyword Environmental enrichment
dc.subject.keyword Exitation-inhibition
dc.subject.keyword Imbalance
dc.subject.keyword Neuroplasticity
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-49129-C2-1-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28575
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16427
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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