Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome

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• dc.contributor.author Catuara Solarz, Silvina, 1986-ca
• dc.contributor.author Espinosa-Carrasco, Joséca
• dc.contributor.author Erb, Ionasca
• dc.contributor.author Langohr, Klausca
• dc.contributor.author Gonzalez, Juan Ramonca
• dc.contributor.author Notredame, Cedricca
• dc.contributor.author Dierssen, Maraca
• dc.date.accessioned 2017-04-24T10:29:47Z
• dc.date.available 2017-04-24T10:29:47Z
• dc.date.issued 2016
• dc.description.abstract Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown. Here, we explored the effects of a combined therapy with environmental enrichment (EE) and EGCG in the Ts65Dn mouse model of DS at young age. Our results show that combined EE-EGCG treatment improved corticohippocampal-dependent learning and memory. Cognitive improvements were accompanied by a rescue of cornu ammonis 1 (CA1) dendritic spine density and a normalization of the proportion of excitatory and inhibitory synaptic markers in CA1 and dentate gyrus.
• dc.description.sponsorship This research was supported by DIUE of Generalitat de Catalunya (Grups consolidats SGR 2014/1125); Fondation Jérôme Lejeune (Paris, France); Spanish Ministry of Economy and Finance (MINECO) grants SAF2013-49129-C2-1-R, BFU2011-28575, and MTM2015-64465-C2-1-R CDTI (“Smartfoods”); the CIBER of Rare Diseases (ISCIII initiative); and EU-Era Net Neuron PCIN-2013-060. The CRG has received support as a Severo Ochoa Center of Excellence SEV- 2012-O208. S.C.-S. received a FPI doctoral Fellowship from the MINECO (SAF2010-16427).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Catuara-Solarz S, Espinosa-Carrasco J, Erb I, Langohr K, Gonzalez JR, Notredame C et al. Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome. eNeuro. 2016;3(5):ENEURO.0103-16.2016. DOI: 10.1523/ENEURO.0103-16.2016
• dc.identifier.doi http://dx.doi.org/10.1523/ENEURO.0103-16.2016
• dc.identifier.issn 2373-2822
• dc.identifier.uri http://hdl.handle.net/10230/30883
• dc.language.iso eng
• dc.publisher Society for Neuroscienceca
• dc.relation.ispartof eNeuro. 2016;3(5):ENEURO.0103-16.2016
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-49129-C2-1-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28575
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16427
• dc.rights Copyright © 2016 Catuara-Solarz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword (-)-Epigallocatechin-3-gallate
• dc.subject.keyword Down syndrome
• dc.subject.keyword Environmental enrichment
• dc.subject.keyword Exitation-inhibition
• dc.subject.keyword Imbalance
• dc.subject.keyword Neuroplasticity
• dc.title Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndromeca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion