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Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.

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dc.contributor.author Blanco, Gonzalo
dc.contributor.author Puiggros Metje, Anna Maria
dc.contributor.author Rodríguez-Rivera, María
dc.contributor.author Gimeno Vázquez, Eva
dc.contributor.author Abella Monreal, Eugenia
dc.contributor.author Ferrer Del Alamo, Ana
dc.contributor.author Espinet Solà, Blanca
dc.date.accessioned 2017-02-08T12:41:57Z
dc.date.available 2017-02-08T12:41:57Z
dc.date.issued 2016
dc.identifier.citation Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo M, Collado R. et al. Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations. Oncotarget. 2016 Dec 6;7(49):80916-80924. doi: 10.18632/oncotarget.13106
dc.identifier.issn 1949-2553
dc.identifier.uri http://hdl.handle.net/10230/28084
dc.description.abstract Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10-year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.
dc.description.sponsorship This work has been supported by the following grants: PI11/01621, PI15/00437, RD09/0076/00036,RD12/0036/0044, RD12/0036/0069 and PT13/0010/0005 FEDER, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness; 2014/SGR585 from Generalitat de Catalunya; “Xarxa de Bancs de tumors” sponsored by Pla Director d’Oncologia de Catalunya (XBTC) and Fundació La Caixa; the Swedish Cancer Society, the Swedish Research Council, the Lion’s Cancer Research Foundation, and Selander’s Foundation, Uppsala; H2020 “AEGLE, An analytics framework for/nintegrated and personalized healthcare services in Europe” by the EU.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Impact Journals
dc.relation.ispartof Oncotarget. 2016 Dec 6;7(49):80916-24
dc.rights All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.subject.other Leucèmia aguda -- Aspectes genètics
dc.subject.other Leucèmia limfocítica
dc.title Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.13106
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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