Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Blanco Ares, Gonzalo, 1989-ca
• dc.contributor.author Puiggros Metje, Anna Mariaca
• dc.contributor.author Rodríguez-Rivera, Maríaca
• dc.contributor.author Gimeno Vázquez, Evaca
• dc.contributor.author Abella Monreal, Eugeniaca
• dc.contributor.author Ferrer Del Alamo, Anaca
• dc.contributor.author Espinet Solà, Blancaca
• dc.date.accessioned 2017-02-08T12:41:57Z
• dc.date.available 2017-02-08T12:41:57Z
• dc.date.issued 2016
• dc.description.abstract Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10-year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.ca
• dc.description.sponsorship This work has been supported by the following grants: PI11/01621, PI15/00437, RD09/0076/00036,RD12/0036/0044, RD12/0036/0069 and PT13/0010/0005 FEDER, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness; 2014/SGR585 from Generalitat de Catalunya; “Xarxa de Bancs de tumors” sponsored by Pla Director d’Oncologia de Catalunya (XBTC) and Fundació La Caixa; the Swedish Cancer Society, the Swedish Research Council, the Lion’s Cancer Research Foundation, and Selander’s Foundation, Uppsala; H2020 “AEGLE, An analytics framework for/nintegrated and personalized healthcare services in Europe” by the EU.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo M, Collado R. et al. Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations. Oncotarget. 2016 Dec 6;7(49):80916-80924. doi: 10.18632/oncotarget.13106ca
• dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.13106
• dc.identifier.issn 1949-2553
• dc.identifier.uri http://hdl.handle.net/10230/28084
• dc.language.iso engca
• dc.publisher Impact Journalsca
• dc.relation.ispartof Oncotarget. 2016 Dec 6;7(49):80916-24
• dc.rights All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri https://creativecommons.org/licenses/by/3.0/ca
• dc.subject.other Leucèmia aguda -- Aspectes genèticsca
• dc.subject.other Leucèmia limfocíticaca
• dc.title Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.ca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca