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Influence of Phenol-Enriched Olive Oils on Human Intestinal Immune Function.

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dc.contributor.author Martín-Peláez, Sandra
dc.contributor.author Castañer, Olga
dc.contributor.author Solà, Rosa
dc.contributor.author Motilva, Maria-José
dc.contributor.author Castell, Margarida
dc.contributor.author Pérez-Cano, Francisco José
dc.contributor.author Fitó Colomer, Montserrat
dc.date.accessioned 2016-07-27T10:26:54Z
dc.date.available 2016-07-27T10:26:54Z
dc.date.issued 2016
dc.identifier.citation Martín-Peláez S, Castañer O, Solà R, Motilva MJ, Castell M, Pérez-Cano FJ. et al. Influence of Phenol-Enriched Olive Oils on Human Intestinal Immune Function. Nutrients. 2016 Apr 11;8(4). pii: E213. doi: 10.3390/nu8040213
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/27217
dc.description.abstract Olive oil (OO) phenolic compounds (PC) are able to influence gut microbial populations and metabolic output. Our aim was to investigate whether these compounds and changes affect the mucosal immune system. In a randomized, controlled, double blind cross-over human trial, for three weeks, preceded by two-week washout periods, 10 hypercholesterolemic participants ingested 25 mL/day of three raw virgin OO differing in their PC concentration and origin: (1) an OO containing 80 mg PC/kg (VOO); (2) a PC-enriched OO containing 500 mg PC/kg from OO (FVOO); and (3) a PC-enriched OO containing a mixture of 500 mg PC/kg from OO and thyme (1:1, FVOOT). Intestinal immunity (fecal immunoglobulin A (IgA) and IgA-coated bacteria) and inflammation markers (C-reactive protein (CRP) and fecal interleukin 6 (IL-6), tumor necrosis factor α (TNFα) and calprotectin) was analyzed. The ingestion of high amounts of OO PC, as contained in FVOO, tended to increase the proportions of IgA-coated bacteria and increased plasma levels of CRP. However, lower amounts of OO PC (VOO) and the combination of two PC sources (FVOOT) did not show significant effects on the variables investigated. Results indicate a potential stimulation of the immune system with very high doses of OO PC, which should be further investigated.
dc.description.sponsorship S.M.-P. was supported by an advanced postdoctoral contract of the ISCIII (Sara Borrell, CD10/00224). O.C. was supported by a research contract of the ISCIII (Juan Rodes, JR14/00008). M.F. was supported by a joint contract of the ISCIII and Health Department of the Catalan Government (Generalitat de Catalunya) (CP 06/00100). The project was also supported by the Spanish Ministry of Economy and Competitveness (MINECO; AGL2009-13517-C03-01, AGL2009-13517-C03-02, AGL2009-13517-C03-03), and by grants from ISCIII FEDER (CB06/03/0028), and AGAUR (2014SGR240)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Nutrients. 2016 Apr 11;8(4):E213
dc.rights This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution/n(CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Oli d'oliva -- Aspectes nutricionals
dc.subject.other Sistema immunològic
dc.title Influence of Phenol-Enriched Olive Oils on Human Intestinal Immune Function.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu8040213
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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