Influence of Phenol-Enriched Olive Oils on Human Intestinal Immune Function.

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  • dc.contributor.author Martín-Peláez, Sandraca
  • dc.contributor.author Castañer, Olgaca
  • dc.contributor.author Solà, Rosaca
  • dc.contributor.author Motilva, Maria-Joséca
  • dc.contributor.author Castell, Margaridaca
  • dc.contributor.author Pérez-Cano, Francisco Joséca
  • dc.contributor.author Fitó Colomer, Montserratca
  • dc.date.accessioned 2016-07-27T10:26:54Z
  • dc.date.available 2016-07-27T10:26:54Z
  • dc.date.issued 2016
  • dc.description.abstract Olive oil (OO) phenolic compounds (PC) are able to influence gut microbial populations and metabolic output. Our aim was to investigate whether these compounds and changes affect the mucosal immune system. In a randomized, controlled, double blind cross-over human trial, for three weeks, preceded by two-week washout periods, 10 hypercholesterolemic participants ingested 25 mL/day of three raw virgin OO differing in their PC concentration and origin: (1) an OO containing 80 mg PC/kg (VOO); (2) a PC-enriched OO containing 500 mg PC/kg from OO (FVOO); and (3) a PC-enriched OO containing a mixture of 500 mg PC/kg from OO and thyme (1:1, FVOOT). Intestinal immunity (fecal immunoglobulin A (IgA) and IgA-coated bacteria) and inflammation markers (C-reactive protein (CRP) and fecal interleukin 6 (IL-6), tumor necrosis factor α (TNFα) and calprotectin) was analyzed. The ingestion of high amounts of OO PC, as contained in FVOO, tended to increase the proportions of IgA-coated bacteria and increased plasma levels of CRP. However, lower amounts of OO PC (VOO) and the combination of two PC sources (FVOOT) did not show significant effects on the variables investigated. Results indicate a potential stimulation of the immune system with very high doses of OO PC, which should be further investigated.ca
  • dc.description.sponsorship S.M.-P. was supported by an advanced postdoctoral contract of the ISCIII (Sara Borrell, CD10/00224). O.C. was supported by a research contract of the ISCIII (Juan Rodes, JR14/00008). M.F. was supported by a joint contract of the ISCIII and Health Department of the Catalan Government (Generalitat de Catalunya) (CP 06/00100). The project was also supported by the Spanish Ministry of Economy and Competitveness (MINECO; AGL2009-13517-C03-01, AGL2009-13517-C03-02, AGL2009-13517-C03-03), and by grants from ISCIII FEDER (CB06/03/0028), and AGAUR (2014SGR240)
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Martín-Peláez S, Castañer O, Solà R, Motilva MJ, Castell M, Pérez-Cano FJ. et al. Influence of Phenol-Enriched Olive Oils on Human Intestinal Immune Function. Nutrients. 2016 Apr 11;8(4). pii: E213. doi: 10.3390/nu8040213ca
  • dc.identifier.doi http://dx.doi.org/10.3390/nu8040213
  • dc.identifier.issn 2072-6643
  • dc.identifier.uri http://hdl.handle.net/10230/27217
  • dc.language.iso engca
  • dc.publisher MDPIca
  • dc.relation.ispartof Nutrients. 2016 Apr 11;8(4):E213
  • dc.rights This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution/n(CC-BY) license (http://creativecommons.org/licenses/by/4.0/).ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Oli d'oliva -- Aspectes nutricionalsca
  • dc.subject.other Sistema immunològicca
  • dc.title Influence of Phenol-Enriched Olive Oils on Human Intestinal Immune Function.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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