Welcome to the UPF Digital Repository

Airborne copper exposure in school environments associated with poorer motor performance and altered basal ganglia.

Show simple item record

dc.contributor.author Pujol Martí, Jesús, 1981-
dc.contributor.author Fenoll, Raquel
dc.contributor.author Macià, Dídac
dc.contributor.author Martínez-Vilavella, Gerard
dc.contributor.author Álvarez Pedrerol, Mar
dc.contributor.author Rivas, Ioar
dc.contributor.author Forns i Guzman, Joan, 1981-
dc.contributor.author Deus, Joan
dc.contributor.author Blanco Hinojo, Laura, 1981-
dc.contributor.author Querol, Xavier
dc.contributor.author Sunyer Deu, Jordi
dc.date.accessioned 2016-07-07T11:14:04Z
dc.date.available 2016-07-07T11:14:04Z
dc.date.issued 2016
dc.identifier.citation Pujol J, Fenoll R, Macià D, Martínez-Vilavella G, Alvarez-Pedrerol M, Rivas I. et al. Airborne copper exposure in school environments associated with poorer motor performance and altered basal ganglia. Brain Behav. 2016 Apr 22;6(6):e00467. doi: 10.1002/brb3.467
dc.identifier.issn 2162-3279
dc.identifier.uri http://hdl.handle.net/10230/27011
dc.description.abstract INTRODUCTION: Children are more vulnerable to the effects of environmental elements. A variety of air pollutants are among the identified factors causing neural damage at toxic concentrations. It is not obvious, however, to what extent the tolerated high levels of air pollutants are able to alter brain development. We have specifically investigated the neurotoxic effects of airborne copper exposure in school environments. METHODS: Speed and consistency of motor response were assessed in 2836 children aged from 8 to 12 years. Anatomical MRI, diffusion tensor imaging, and functional MRI were used to directly test the brain repercussions in a subgroup of 263 children. RESULTS: Higher copper exposure was associated with poorer motor performance and altered structure of the basal ganglia. Specifically, the architecture of the caudate nucleus region was less complete in terms of both tissue composition and neural track water diffusion. Functional MRI consistently showed a reciprocal connectivity reduction between the caudate nucleus and the frontal cortex./nCONCLUSIONS: The results establish an association between environmental copper exposure in children and alterations of basal ganglia structure and function.
dc.description.sponsorship This work was supported by the European Research Council under the ERC (grant number 268479)—the BREATHE project. The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Group SGR2014-1673.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Willey
dc.rights ª 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Aire -- Contaminació
dc.subject.other Infants -- Desenvolupament
dc.title Airborne copper exposure in school environments associated with poorer motor performance and altered basal ganglia.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/brb3.467
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking