Airborne copper exposure in school environments associated with poorer motor performance and altered basal ganglia.
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- dc.contributor.author Pujol Martí, Jesús, 1981-ca
- dc.contributor.author Fenoll, Raquelca
- dc.contributor.author Macià, Dídacca
- dc.contributor.author Martínez-Vilavella, Gerardca
- dc.contributor.author Álvarez Pedrerol, Marca
- dc.contributor.author Rivas, Ioarca
- dc.contributor.author Forns i Guzman, Joan, 1981-ca
- dc.contributor.author Deus, Joanca
- dc.contributor.author Blanco Hinojo, Laura, 1981-ca
- dc.contributor.author Querol, Xavierca
- dc.contributor.author Sunyer Deu, Jordica
- dc.date.accessioned 2016-07-07T11:14:04Z
- dc.date.available 2016-07-07T11:14:04Z
- dc.date.issued 2016
- dc.description.abstract INTRODUCTION: Children are more vulnerable to the effects of environmental elements. A variety of air pollutants are among the identified factors causing neural damage at toxic concentrations. It is not obvious, however, to what extent the tolerated high levels of air pollutants are able to alter brain development. We have specifically investigated the neurotoxic effects of airborne copper exposure in school environments. METHODS: Speed and consistency of motor response were assessed in 2836 children aged from 8 to 12 years. Anatomical MRI, diffusion tensor imaging, and functional MRI were used to directly test the brain repercussions in a subgroup of 263 children. RESULTS: Higher copper exposure was associated with poorer motor performance and altered structure of the basal ganglia. Specifically, the architecture of the caudate nucleus region was less complete in terms of both tissue composition and neural track water diffusion. Functional MRI consistently showed a reciprocal connectivity reduction between the caudate nucleus and the frontal cortex./nCONCLUSIONS: The results establish an association between environmental copper exposure in children and alterations of basal ganglia structure and function.ca
- dc.description.sponsorship This work was supported by the European Research Council under the ERC (grant number 268479)—the BREATHE project. The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Group SGR2014-1673.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Pujol J, Fenoll R, Macià D, Martínez-Vilavella G, Alvarez-Pedrerol M, Rivas I. et al. Airborne copper exposure in school environments associated with poorer motor performance and altered basal ganglia. Brain Behav. 2016 Apr 22;6(6):e00467. DOI: 10.1002/brb3.467ca
- dc.identifier.doi http://dx.doi.org/10.1002/brb3.467
- dc.identifier.issn 2162-3279
- dc.identifier.uri http://hdl.handle.net/10230/27011
- dc.language.iso engca
- dc.publisher Willeyca
- dc.relation.ispartof Brain and Behavior. 2016 Apr 22;6(6):e00467
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
- dc.rights © 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Aire -- Contaminacióca
- dc.subject.other Infants -- Desenvolupamentca
- dc.title Airborne copper exposure in school environments associated with poorer motor performance and altered basal ganglia.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca