Autophagy: a decisive process for stemness

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Document Type: Article
Version: Published version
Date: 2016
This document is associated with a Creative Common license Published originally by Impact Journals at http://dx.doi.org/10.18632/oncotarget.7766 under a Creative Commons Attribution 3.0 License.
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Citation: García-Prat L, Martínez-Vicente M, Muñoz-Cánoves P. Autophagy: a decisive process for stemness. Oncotarget. 2016; 7(11): 12286-12288. DOI 10.18632/oncotarget.7766
Permanent link: http://hdl.handle.net/10230/26920

Abstract:

Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.
Author: García Prat, Laura ; Martínez Vicente, Marta ; Muñoz Cánoves, Pura, 1962-
DOI: http://dx.doi.org/10.18632/oncotarget.7766

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