Welcome to the UPF Digital Repository

Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD

Show simple item record

dc.contributor.author Ramon, Maria Antonia
dc.contributor.author Ferrer, Jaume
dc.contributor.author Gimeno Santos, Elena, 1980-
dc.contributor.author Donaire González, David
dc.contributor.author Rodríguez, Esther
dc.contributor.author Balcells Vilarnau, Eva, 1967-
dc.contributor.author De Batlle, Jordi
dc.contributor.author Benet, Marta
dc.contributor.author Guerra, Stefano
dc.contributor.author Sauleda Roig, Jaume
dc.contributor.author Ferrer, Antoni-Lluc, 1942-
dc.contributor.author Farrero, Eva
dc.contributor.author Gea Guiral, Joaquim
dc.contributor.author Barberà, Joan Albert
dc.contributor.author Agustí, Alvar
dc.contributor.author Rodríguez Roisin, Robert
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author García Aymerich, Judith
dc.contributor.author PAC-COPD Study Group
dc.date.accessioned 2016-05-23T13:43:33Z
dc.date.issued 2016
dc.identifier.citation Ramon MA, Ferrer J, Gimeno-Santos E, Donaire-Gonzalez D, Rodríguez E, Balcells E et al. Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology. 2016; 21(3): 476-482. DOI 10.1111/resp.12723
dc.identifier.issn 1323-7799
dc.identifier.uri http://hdl.handle.net/10230/26328
dc.description.abstract BACKGROUND AND OBJECTIVE: Exercise capacity decline is a predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Static pulmonary hyperinflation is a key determinant of exercise performance, but its effect on the longitudinal decline in exercise capacity remains unknown. We aimed to study the relationship between the inspiratory capacity-to-total lung capacity (IC/TLC) ratio and exercise capacity decline in COPD. METHODS: We measured IC/TLC and other relevant clinical and functional variables in 342 clinically stable patients with COPD. The 6-min walk distance (6MWD) was determined at recruitment and after a mean ± SD of 1.7 ± 0.3 years. The annual rate of change in 6MWD was calculated. Multiple imputation to account for losses during follow up was implemented, and multivariate regression was used to analyze predictive factors of 6MWD decline. RESULTS: Mean decline rate in the 6MWD was 21.9 ± 34.1 m/year. In the bivariate analysis, patients with lower levels of IC/TLC had greater 6MWD decline (-27.4 ± 42.5, -24.9 ± 36.5 and -13.4 ± 39.9 m/year in the first, second and third tertile of IC/TLC, respectively; P-for-trend = 0.018). From other potential risk factors considered, dyspnoea, health status, serum C-reactive protein and Borg dyspnoea score at the end of the exercise test were related to exercise capacity decline. In the multivariate regression model, only IC/TLC (β = 0.7 m/year per each percentage unit of IC/TLC; P = 0.007) and dyspnoea (mMRC ≥ 2) (β = -14.6 m/year; P = 0.013) were associated with the annual rate of 6MWD change. CONCLUSION: IC/TLC and dyspnoea in clinically stable patients with COPD predict their exercise capacity decline and may help to guide early therapeutic interventions.
dc.description.sponsorship The PAC-COPD Study is funded by grants from Fondo de Investigación Sanitaria (FIS PI020541), Ministry of Health, Spain; Agència d’Avaluació de Tecnologia i Recerca Mèdiques (AATRM 035/20/02), Catalonia Government; Spanish Society of Pneumology and Thoracic Surgery (SEPAR 2002/137); Catalan Foundation of Pneumology (FUCAP 2003 Beca Marià Ravà); Red RESPIRA (RTIC C03/11); Red RCESP (RTIC C03/09), Fondo de Investigación Sanitaria (PI052486); Fondo de Investigación Sanitaria (PI052302); Fundació La Marató de TV3 (num. 041110); DURSI (2005SGR00392); and unrestricted educational grants from Novartis Farmacèutica, Spain, and AstraZeneca Farmacéutica, Spain. CIBERESP and CIBERES are funded by the Instituto de Salud Carlos III, Ministry of Health, Spain.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Respirology. 2016; 21(3): 476-482
dc.rights This is the pre-peer reviewed version of the following article: Ramon MA, Ferrer J, Gimeno-Santos E, Donaire-Gonzalez D, Rodríguez E, Balcells E et al. Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology. 2016; 21(3): 476-482. DOI 10.1111/resp.12723, which has been published in final form at http://dx.doi.org10.1111/resp.12723. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.subject.other Pulmons -- Malalties obstructives
dc.title Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/resp.12723
dc.subject.keyword 6-min walk distance
dc.subject.keyword Chronic obstructive pulmonary disease
dc.subject.keyword Cohort study
dc.subject.keyword Disease progression
dc.subject.keyword Exercise capacity
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2017-05-01
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2017-05-01


This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking