Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD

Ramon, Maria Antonia; Ferrer, Jaume; Gimeno Santos, Elena, 1980-; Donaire González, David; Rodríguez, Esther; Balcells Vilarnau, Eva, 1967-; De Batlle, Jordi; Benet, Marta; Guerra, Stefano; Sauleda Roig, Jaume; Ferrer, Antoni-Lluc, 1942-; Farrero, Eva; Gea Guiral, Joaquim; Barberà, Joan Albert; Agustí García-Navarro, Àlvar; Rodríguez-Roisin, Robert; Antó i Boqué, Josep Maria; García Aymerich, Judith; PAC-COPD Study Group

Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD

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dc.contributor.author Ramon, Maria Antoniaca
dc.contributor.author Ferrer, Jaumeca
dc.contributor.author Gimeno Santos, Elena, 1980-ca
dc.contributor.author Donaire González, Davidca
dc.contributor.author Rodríguez, Estherca
dc.contributor.author Balcells Vilarnau, Eva, 1967-ca
dc.contributor.author De Batlle, Jordica
dc.contributor.author Benet, Martaca
dc.contributor.author Guerra, Stefanoca
dc.contributor.author Sauleda Roig, Jaumeca
dc.contributor.author Ferrer, Antoni-Lluc, 1942-ca
dc.contributor.author Farrero, Evaca
dc.contributor.author Gea Guiral, Joaquimca
dc.contributor.author Barberà, Joan Albertca
dc.contributor.author Agustí García-Navarro, Àlvarca
dc.contributor.author Rodríguez-Roisin, Robertca
dc.contributor.author Antó i Boqué, Josep Mariaca
dc.contributor.author García Aymerich, Judithca
dc.contributor.author PAC-COPD Study Groupca
dc.date.accessioned 2016-05-23T13:43:33Z
dc.date.issued 2016
dc.description.abstract BACKGROUND AND OBJECTIVE: Exercise capacity decline is a predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Static pulmonary hyperinflation is a key determinant of exercise performance, but its effect on the longitudinal decline in exercise capacity remains unknown. We aimed to study the relationship between the inspiratory capacity-to-total lung capacity (IC/TLC) ratio and exercise capacity decline in COPD. METHODS: We measured IC/TLC and other relevant clinical and functional variables in 342 clinically stable patients with COPD. The 6-min walk distance (6MWD) was determined at recruitment and after a mean ± SD of 1.7 ± 0.3 years. The annual rate of change in 6MWD was calculated. Multiple imputation to account for losses during follow up was implemented, and multivariate regression was used to analyze predictive factors of 6MWD decline. RESULTS: Mean decline rate in the 6MWD was 21.9 ± 34.1 m/year. In the bivariate analysis, patients with lower levels of IC/TLC had greater 6MWD decline (-27.4 ± 42.5, -24.9 ± 36.5 and -13.4 ± 39.9 m/year in the first, second and third tertile of IC/TLC, respectively; P-for-trend = 0.018). From other potential risk factors considered, dyspnoea, health status, serum C-reactive protein and Borg dyspnoea score at the end of the exercise test were related to exercise capacity decline. In the multivariate regression model, only IC/TLC (β = 0.7 m/year per each percentage unit of IC/TLC; P = 0.007) and dyspnoea (mMRC ≥ 2) (β = -14.6 m/year; P = 0.013) were associated with the annual rate of 6MWD change. CONCLUSION: IC/TLC and dyspnoea in clinically stable patients with COPD predict their exercise capacity decline and may help to guide early therapeutic interventions.ca
dc.description.sponsorship The PAC-COPD Study is funded by grants from Fondo de Investigación Sanitaria (FIS PI020541), Ministry of Health, Spain; Agència d’Avaluació de Tecnologia i Recerca Mèdiques (AATRM 035/20/02), Catalonia Government; Spanish Society of Pneumology and Thoracic Surgery (SEPAR 2002/137); Catalan Foundation of Pneumology (FUCAP 2003 Beca Marià Ravà); Red RESPIRA (RTIC C03/11); Red RCESP (RTIC C03/09), Fondo de Investigación Sanitaria (PI052486); Fondo de Investigación Sanitaria (PI052302); Fundació La Marató de TV3 (num. 041110); DURSI (2005SGR00392); and unrestricted educational grants from Novartis Farmacèutica, Spain, and AstraZeneca Farmacéutica, Spain. CIBERESP and CIBERES are funded by the Instituto de Salud Carlos III, Ministry of Health, Spain.
dc.format.mimetype application/pdfca
dc.identifier.citation Ramon MA, Ferrer J, Gimeno-Santos E, Donaire-Gonzalez D, Rodríguez E, Balcells E et al. Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology. 2016;21(3):476-82. DOI: 10.1111/resp.12723ca
dc.identifier.doi http://dx.doi.org/10.1111/resp.12723
dc.identifier.issn 1323-7799
dc.identifier.uri http://hdl.handle.net/10230/26328
dc.language.iso engca
dc.publisher Wileyca
dc.relation.ispartof Respirology. 2016;21(3):476-82
dc.rights This is the pre-peer reviewed version of the following article: Ramon MA, Ferrer J, Gimeno-Santos E, Donaire-Gonzalez D, Rodríguez E, Balcells E et al. Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology. 2016; 21(3): 476-482. DOI 10.1111/resp.12723, which has been published in final form at http://dx.doi.org10.1111/resp.12723. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.keyword 6-min walk distance
dc.subject.keyword Chronic obstructive pulmonary disease
dc.subject.keyword Cohort study
dc.subject.keyword Disease progression
dc.subject.keyword Exercise capacity
dc.subject.other Pulmons -- Malalties obstructivesca
dc.title Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPDca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/acceptedVersionca

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