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GEMC1 is a critical regulator of multiciliated cell differentiation.

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dc.contributor.author Terré, Berta
dc.contributor.author Piergiovanni, Gabriele
dc.contributor.author Segura-Bayona, Sandra
dc.contributor.author Gil Gómez, Gabriel
dc.contributor.author Youssef, Sameh A.
dc.contributor.author Attolini, Camille Stephan-Otto
dc.contributor.author Wilsch-Bräuninger, Michaela
dc.contributor.author Jung, Carole
dc.contributor.author Rojas Mendoza, Ana Maria
dc.contributor.author Marjanovi c, Marko
dc.contributor.author Knobel, Philip A.
dc.contributor.author Palenzuela, Lluís
dc.contributor.author López-Rovira, Teresa
dc.contributor.author Forrow, Stephen
dc.contributor.author Huttner, Wieland B.
dc.contributor.author Valverde, M. A. (Miguel Ángel), 1963-
dc.contributor.author de Bruin, Alain
dc.contributor.author Costanzo, Vincenzo
dc.contributor.author Stracker, Travis
dc.date.accessioned 2016-05-19T10:56:48Z
dc.date.issued 2016
dc.identifier.citation Terré B1, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS. et al. GEMC1 is a critical regulator of multiciliated cell differentiation. EMBO J. 2016 May 2;35(9):942-60. DOI: 10.15252/embj.201592821.
dc.identifier.issn 0261-4189
dc.identifier.uri http://hdl.handle.net/10230/26303
dc.description.abstract The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass of mucociliary clearance disorders termed reduced generation of multiple motile cilia (RGMC). To date, only two genes, Multicilin (MCIDAS) and cyclin O (CCNO) have been identified in this disorder in humans.
dc.description.sponsorship We thank the Ministerio de Economía y Competitividad (MINECO) for funding to TS (BFU2012-39521) and MAV (SAF2012-38140; Fondo de Investigación Sanitaria (RD12/0042/0014); FEDER Funds); G.G.-G. is supported by ISCIII (PI13/00864); V.C. is funded by the Associazione Italiana per Ricerca sul Cancro (AIRC), the European Research Council (ERC) consolidator grant (614541), the Association for International Cancer Research (AICR) (13-0026), the Giovanni Armenise Award to V.C., the Epigen Progetto Bandiera (4.7) and the Fondazione Telethon (GGP13071); G.P. was supported by AIRC Borsa: Fondazione Giovanna Ciani Rif. 16444; S.S.B. was supported by a fellowship from Fundació La Caixa; P.A.K. was supported by an Early Postdoc Mobility Fellowship from the Swiss National Science Foundation; and B.T. was supported by a Severo Ochoa FPI Fellowship (MINECO). IRB Barcelona is a Severo Ochoa Award of Excellence Recipient (MINECO).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher EMBO Press
dc.relation.ispartof EMBO Journal. 2016 May 2;35(9):942-60
dc.rights © Wiley-Blackwell. The definitive version is available online at: http://dx.doi.org/10.15252/embj.201592821
dc.subject.other Hidrocefàlia
dc.subject.other Esterilitat
dc.title GEMC1 is a critical regulator of multiciliated cell differentiation.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.15252/embj.201592821
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/614541
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-38140
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-39521
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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