GEMC1 is a critical regulator of multiciliated cell differentiation.

Terré, Berta; Piergiovanni, Gabriele; Segura-Bayona, Sandra; Gil Gómez, Gabriel; Youssef, Sameh A.; Attolini, Camille Stephan-Otto; Wilsch-Bräuninger, Michaela; Jung, Carole; Rojas Mendoza, Ana Maria; Marjanovi c, Marko; Knobel, Philip A.; Palenzuela, Lluís; López-Rovira, Teresa; Forrow, Stephen; Huttner, Wieland B.; Valverde, M. A. (Miguel Ángel), 1963-; de Bruin, Alain; Costanzo, Vincenzo; Stracker, Travis

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dc.contributor.author	Terré, Berta
dc.contributor.author	Piergiovanni, Gabriele
dc.contributor.author	Segura-Bayona, Sandra
dc.contributor.author	Gil Gómez, Gabriel
dc.contributor.author	Youssef, Sameh A.
dc.contributor.author	Attolini, Camille Stephan-Otto
dc.contributor.author	Wilsch-Bräuninger, Michaela
dc.contributor.author	Jung, Carole
dc.contributor.author	Rojas Mendoza, Ana Maria
dc.contributor.author	Marjanovi c, Marko
dc.contributor.author	Knobel, Philip A.
dc.contributor.author	Palenzuela, Lluís
dc.contributor.author	López-Rovira, Teresa
dc.contributor.author	Forrow, Stephen
dc.contributor.author	Huttner, Wieland B.
dc.contributor.author	Valverde, M. A. (Miguel Ángel), 1963-
dc.contributor.author	de Bruin, Alain
dc.contributor.author	Costanzo, Vincenzo
dc.contributor.author	Stracker, Travis
dc.date.accessioned	2016-05-19T10:56:48Z
dc.date.issued	2016
dc.identifier.citation	Terré B1, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS. et al. GEMC1 is a critical regulator of multiciliated cell differentiation. EMBO J. 2016 May 2;35(9):942-60. DOI: 10.15252/embj.201592821.
dc.identifier.issn	0261-4189
dc.identifier.uri	http://hdl.handle.net/10230/26303
dc.description.abstract	The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass of mucociliary clearance disorders termed reduced generation of multiple motile cilia (RGMC). To date, only two genes, Multicilin (MCIDAS) and cyclin O (CCNO) have been identified in this disorder in humans.
dc.description.sponsorship	We thank the Ministerio de Economía y Competitividad (MINECO) for funding to TS (BFU2012-39521) and MAV (SAF2012-38140; Fondo de Investigación Sanitaria (RD12/0042/0014); FEDER Funds); G.G.-G. is supported by ISCIII (PI13/00864); V.C. is funded by the Associazione Italiana per Ricerca sul Cancro (AIRC), the European Research Council (ERC) consolidator grant (614541), the Association for International Cancer Research (AICR) (13-0026), the Giovanni Armenise Award to V.C., the Epigen Progetto Bandiera (4.7) and the Fondazione Telethon (GGP13071); G.P. was supported by AIRC Borsa: Fondazione Giovanna Ciani Rif. 16444; S.S.B. was supported by a fellowship from Fundació La Caixa; P.A.K. was supported by an Early Postdoc Mobility Fellowship from the Swiss National Science Foundation; and B.T. was supported by a Severo Ochoa FPI Fellowship (MINECO). IRB Barcelona is a Severo Ochoa Award of Excellence Recipient (MINECO).
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	EMBO Press
dc.relation.ispartof	EMBO Journal. 2016 May 2;35(9):942-60
dc.rights	© Wiley-Blackwell. The definitive version is available online at: http://dx.doi.org/10.15252/embj.201592821
dc.subject.other	Hidrocefàlia
dc.subject.other	Esterilitat
dc.title	GEMC1 is a critical regulator of multiciliated cell differentiation.
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.15252/embj.201592821
dc.relation.projectID	info:eu-repo/grantAgreement/EC/FP7/614541
dc.relation.projectID	info:eu-repo/grantAgreement/ES/3PN/SAF2012-38140
dc.relation.projectID	info:eu-repo/grantAgreement/ES/3PN/BFU2012-39521
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.type.version	info:eu-repo/semantics/acceptedVersion