GEMC1 is a critical regulator of multiciliated cell differentiation.

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• dc.contributor.author Terré, Bertaca
• dc.contributor.author Piergiovanni, Gabrieleca
• dc.contributor.author Segura-Bayona, Sandraca
• dc.contributor.author Gil Gómez, Gabrielca
• dc.contributor.author Youssef, Sameh A.ca
• dc.contributor.author Attolini, Camille Stephan-Ottoca
• dc.contributor.author Wilsch-Bräuninger, Michaelaca
• dc.contributor.author Jung, Caroleca
• dc.contributor.author Rojas Mendoza, Ana Mariaca
• dc.contributor.author Marjanovi c, Markoca
• dc.contributor.author Knobel, Philip A.ca
• dc.contributor.author Palenzuela, Lluísca
• dc.contributor.author López-Rovira, Teresaca
• dc.contributor.author Forrow, Stephenca
• dc.contributor.author Huttner, Wieland B.ca
• dc.contributor.author Valverde, M. A. (Miguel Ángel), 1963-ca
• dc.contributor.author de Bruin, Alainca
• dc.contributor.author Costanzo, Vincenzoca
• dc.contributor.author Stracker, Travisca
• dc.date.accessioned 2016-05-19T10:56:48Z
• dc.date.issued 2016
• dc.description.abstract The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass of mucociliary clearance disorders termed reduced generation of multiple motile cilia (RGMC). To date, only two genes, Multicilin (MCIDAS) and cyclin O (CCNO) have been identified in this disorder in humans.ca
• dc.description.sponsorship We thank the Ministerio de Economía y Competitividad (MINECO) for funding to TS (BFU2012-39521) and MAV (SAF2012-38140; Fondo de Investigación Sanitaria (RD12/0042/0014); FEDER Funds); G.G.-G. is supported by ISCIII (PI13/00864); V.C. is funded by the Associazione Italiana per Ricerca sul Cancro (AIRC), the European Research Council (ERC) consolidator grant (614541), the Association for International Cancer Research (AICR) (13-0026), the Giovanni Armenise Award to V.C., the Epigen Progetto Bandiera (4.7) and the Fondazione Telethon (GGP13071); G.P. was supported by AIRC Borsa: Fondazione Giovanna Ciani Rif. 16444; S.S.B. was supported by a fellowship from Fundació La Caixa; P.A.K. was supported by an Early Postdoc Mobility Fellowship from the Swiss National Science Foundation; and B.T. was supported by a Severo Ochoa FPI Fellowship (MINECO). IRB Barcelona is a Severo Ochoa Award of Excellence Recipient (MINECO).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Terré B1, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS. et al. GEMC1 is a critical regulator of multiciliated cell differentiation. EMBO J. 2016 May 2;35(9):942-60. DOI: 10.15252/embj.201592821.ca
• dc.identifier.doi http://dx.doi.org/10.15252/embj.201592821
• dc.identifier.issn 0261-4189
• dc.identifier.uri http://hdl.handle.net/10230/26303
• dc.language.iso engca
• dc.publisher EMBO Pressca
• dc.relation.ispartof EMBO Journal. 2016 May 2;35(9):942-60
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/614541
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-38140
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-39521
• dc.rights © Wiley-Blackwell. The definitive version is available online at: http://dx.doi.org/10.15252/embj.201592821ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Hidrocefàliaca
• dc.subject.other Esterilitatca
• dc.title GEMC1 is a critical regulator of multiciliated cell differentiation.ca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca